[Correlation between interleukin 4 (IL-4) expression and allergen sensitization in allergic rhinitis patients].

Q3 Medicine

Revista alergia Mexico Pub Date : 2021-04-01 DOI:10.29262/ram.v658i2.800

Asti Widuri

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Abstract

Objective: The objective of this research was to measure the correlation of the expression of IL-4 with allergen sensitization in patients with allergic rhinitis.

Methods: Descriptive analytics was used as a method in this research, with a cross-sectional approach. The subjects were 37 persons with allergic rhinitis who met the inclusion and exclusion criteria. This research was conducted in patients with clinical manifestations of symptoms of allergic rhinitis, and skin prick tests were carried out with ten types of allergens, which are: house dust, cotton, chicken feathers, shrimp, tuna, chicken egg-yolk, chicken egg-white, peanuts, tea, and chocolate. Venous blood sampling was performed for the Interleukin-4 (IL-4) test by using an ELISA device.

Results: The respondents were 37 patients with allergic rhinitis, of which 26 (70.3 %) were women and 11 (29.7 %) were men. The highest sensitivity to inhaled allergens in patients with rhinitis was to house dust in 31 samples (83.8 %). The correlation of the expression of IL-4 with sensitization to allergens in patients with allergic rhinitis based on the Spearman test resulted in p > 0.05, not significant with some allergens in a negative correlation.

Conclusion: There was no significant correlation between the expression of IL-4 and the sensitization to allergens in patients with allergic rhinitis.

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[变应性鼻炎患者白细胞介素4 (IL-4)表达与过敏原致敏的相关性]。

目的:探讨变应性鼻炎患者IL-4表达与过敏原致敏的相关性。方法:本研究采用横断面方法，采用描述性分析方法。受试者为37例符合纳入和排除标准的变应性鼻炎患者。本研究对有变应性鼻炎症状临床表现的患者进行皮肤点刺试验，对10种过敏原进行皮肤点刺试验，分别是:室内灰尘、棉花、鸡毛、虾、金枪鱼、鸡蛋蛋黄、鸡蛋清、花生、茶、巧克力。采用ELISA装置采集静脉血进行白细胞介素-4 (IL-4)检测。结果:37例变应性鼻炎患者中，女性26例(70.3%)，男性11例(29.7%)。鼻炎患者对吸入性过敏原最敏感的是31例(83.8%)室内灰尘。根据Spearman检验，变应性鼻炎患者IL-4表达与变应原致敏性的相关性p > 0.05，部分变应原呈负相关，差异不显著。结论:变应性鼻炎患者IL-4的表达与变应原致敏性无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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