A novel parotid carcinoma with a prominent ghost cell population: a masquerading tumor or "salivary ghost cell carcinoma"?

IF 1.2 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2022-03-01 Epub Date: 2021-08-14 DOI:10.1007/s00795-021-00302-9

Hiroshi Harada, Mitsuo P Sato, Naoki Otsuki, Mao Kawamura, Akira Kurose, Takao Satou

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引用次数: 3

Abstract

Ghost cell is one of several unique cellular morphologies associated with aberrant keratinization. We encountered a novel parotid tumor containing numerous ghost cells and herein describe its histological features and discuss diagnostic problems. The patient was a 90-year-old Japanese male, who complained of swelling of the left parotid area for four months. Positron emission tomography indicated no cervical lymph node metastasis or distant metastasis. The tumor was successfully resected with no signs of recurrence or metastasis for six months after surgery. Histologically, the tumor was mainly composed of squamous cells forming irregularly shaped nests with a mixture of pleomorphic giant or multinucleated cells and bland basaloid cell. Keratinized areas were occupied by a prominent ghost cell population. Immunohistochemically, CK5/6 and CK19 were widely positive as well as AE1/AE3, p40 and p63. Nuclear expression of β-catenin was also observed. The present case can be regarded as a particular form of squamous cell carcinoma and is believed to contain a large number of ghost cells resulting from an unclear mechanism. However, it seems difficult to consider such tumors as a clinicopathologically independent entity at present. Applying a term such as "salivary ghost cell carcinoma" would be premature.

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新型腮腺癌伴明显的鬼细胞群:是伪装肿瘤还是“唾液鬼细胞癌”?

鬼细胞是与异常角化有关的几种独特的细胞形态之一。我们遇到一个新的腮腺肿瘤含有大量的鬼细胞，在此描述其组织学特征和讨论诊断问题。患者为90岁日本男性，主诉左侧腮腺肿大4个月。正电子发射断层扫描未见颈部淋巴结转移及远处转移。肿瘤成功切除，术后6个月无复发或转移迹象。组织学上，肿瘤主要由鳞状细胞组成，形成不规则形状的巢，多形性巨细胞或多核细胞与淡色基底样细胞混合。角化区被一个突出的鬼细胞群占据。免疫组化结果显示，CK5/6、CK19、AE1/AE3、p40、p63广泛阳性。β-catenin的核表达也被观察到。本病例可视为鳞状细胞癌的一种特殊形式，据信含有大量鬼细胞，其机制尚不清楚。然而，目前似乎很难将此类肿瘤视为临床病理学上独立的实体。使用“唾液鬼影细胞癌”这样的术语还为时过早。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.