PDLIM1: Structure, function and implication in cancer.

IF 4.1 Q2 CELL BIOLOGY

Cell Stress Pub Date : 2021-07-26 eCollection Date: 2021-08-01 DOI:10.15698/cst2021.08.254

Jian-Kang Zhou, Xin Fan, Jian Cheng, Wenrong Liu, Yong Peng

引用次数: 9

Abstract

PDLIM1, a member of the PDZ-LIM family, is a cytoskeletal protein and functions as a platform to form distinct protein complexes, thus participating in multiple physiological processes such as cytoskeleton regulation and synapse formation. Emerging evidence demonstrates that PDLIM1 is dysregualted in a variety of tumors and plays essential roles in tumor initiation and progression. In this review, we summarize the structure and function of PDLIM1, as well as its important roles in human cancers.

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PDLIM1:结构、功能及其在癌症中的意义。

PDLIM1是PDZ-LIM家族成员之一，是一种细胞骨架蛋白，作为形成不同蛋白复合物的平台，参与细胞骨架调节、突触形成等多种生理过程。越来越多的证据表明，PDLIM1在多种肿瘤中失调，并在肿瘤的发生和发展中发挥重要作用。本文就PDLIM1的结构、功能及其在人类癌症中的重要作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.