Pairwise correlation of genes involved in glucose metabolism: a potential diagnostic marker of cancer?

Q2 Biochemistry, Genetics and Molecular Biology

Genes and Cancer Pub Date : 2021-06-17 eCollection Date: 2021-01-01 DOI:10.18632/genesandcancer.216

Meena Kishore Sakharkar, Karthic Rajamanickam, Shaoping Ji, Sarinder Kaur Dhillon, Jian Yang

{"title":"Pairwise correlation of genes involved in glucose metabolism: a potential diagnostic marker of cancer?","authors":"Meena Kishore Sakharkar, Karthic Rajamanickam, Shaoping Ji, Sarinder Kaur Dhillon, Jian Yang","doi":"10.18632/genesandcancer.216","DOIUrl":null,"url":null,"abstract":"Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer. In total, 127 genes were examined for their gene expression levels and pairwise gene correlations. Genes ADH1B and PDHA2 were differentially expressed in most of the 12 types of cancer and five pairs of genes exhibited consistent correlation changes (from strong correlations in normal controls to weak correlations in cancer patients) across all types of cancer. Thus, the two differentially expressed genes and five gene pairs could be potential diagnostic markers for cancer. Further preclinical and clinical studies are warranted to prove whether these genes and/or gene pairs would indeed aid in early diagnosis of cancer.","PeriodicalId":38987,"journal":{"name":"Genes and Cancer","volume":" ","pages":"69-76"},"PeriodicalIF":0.0000,"publicationDate":"2021-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211569/pdf/","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes and Cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18632/genesandcancer.216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 3

Abstract

Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer. In total, 127 genes were examined for their gene expression levels and pairwise gene correlations. Genes ADH1B and PDHA2 were differentially expressed in most of the 12 types of cancer and five pairs of genes exhibited consistent correlation changes (from strong correlations in normal controls to weak correlations in cancer patients) across all types of cancer. Thus, the two differentially expressed genes and five gene pairs could be potential diagnostic markers for cancer. Further preclinical and clinical studies are warranted to prove whether these genes and/or gene pairs would indeed aid in early diagnosis of cancer.

Abstract Image

查看原文本刊更多论文

参与糖代谢的基因的两两相关:癌症的潜在诊断标记?

癌症是一种高度恶性的疾病，2020年全球约有1000万人死于癌症。癌症患者的生存很大程度上依赖于早期诊断。在这项研究中，我们评估了参与葡萄糖代谢的基因是否可以作为癌症的潜在诊断标志物。总共检测了127个基因的基因表达水平和成对基因相关性。基因ADH1B和PDHA2在12种类型的癌症中表达差异，5对基因在所有类型的癌症中表现出一致的相关性变化(从正常对照的强相关性到癌症患者的弱相关性)。因此，这两个差异表达基因和5对基因可能是潜在的癌症诊断标记。需要进一步的临床前和临床研究来证明这些基因和/或基因对是否确实有助于癌症的早期诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Genes and Cancer Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.90

自引率

0.00%

发文量