The Phenomenon of Multidrug Resistance in Glioblastomas.

Q1 Medicine

Hematology/ Oncology and Stem Cell Therapy Pub Date : 2022-06-01 DOI:10.1016/j.hemonc.2021.05.006

Alexandr N Chernov, Diana A Alaverdian, Elvira S Galimova, Alessandra Renieri, Elisa Frullanti, Ilaria Meloni, Olga V Shamova

引用次数: 11

Abstract

The most common and aggressive brain tumor in the adult population is glioblastoma (GBM). The lifespan of patients does not exceed 22 months. One of the reasons for the low effectiveness of GBM treatment is its radioresistance and chemoresistance. In the current review, we discuss the phenomenon of multidrug resistance of GBM in the context of the expression of ABC family transporter proteins and the mechanisms of proliferation, angiogenesis, and recurrence. We focused on the search of molecular targets among growth factors, receptors, signal transduction proteins, microRNAs, transcription factors, proto-oncogenes, tumor suppressor genes, and their single-nucleotide polymorphisms.

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胶质母细胞瘤的多药耐药现象。

成人人群中最常见和侵袭性的脑肿瘤是胶质母细胞瘤(GBM)。患者的生存期不超过22个月。GBM治疗效果低的原因之一是其放射耐药和化学耐药。本文从ABC家族转运蛋白的表达、增殖、血管生成和复发机制等方面探讨了GBM的多药耐药现象。我们专注于在生长因子、受体、信号转导蛋白、microrna、转录因子、原癌基因、肿瘤抑制基因及其单核苷酸多态性中寻找分子靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hematology/ Oncology and Stem Cell Therapy Medicine-Hematology

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

27 weeks

期刊介绍： Hematology Oncology and Stem Cell Therapy is an international, peer-reviewed, open access journal that provides a vehicle for publications of high-quality clinical as well as basic science research reports in hematology and oncology. The contents of the journal also emphasize the growing importance of hematopoietic stem cell therapy for treatment of various benign and malignant hematologic disorders and certain solid tumors.The journal prioritizes publication of original research articles but also would give consideration for brief reports, review articles, special communications, and unique case reports. It also offers a special section for clinically relevant images that provide an important educational value.