Fluorotelomer Alcohols' Toxicology Correlates with Oxidative Stress and Metabolism.

IF 6.1 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Yujuan Yang, Kuiyu Meng, Min Chen, Shuyu Xie, Dongmei Chen
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引用次数: 1

Abstract

Fluorotelomer alcohols (FTOHs) are widely used as industrial raw materials due to their unique hydrophobic and oleophobic properties. However, because of accidental exposure to products containing FTOHs or with the widespread use of FTOHs, they tend to contaminate the water and the soil. There are reports demonstrating that FTOHs can cause various harmful effects in animals and humans (for example, neurotoxicity, hepatotoxicity, nephrotoxicity, immunotoxicity, endocrine-disrupting activity, and developmental and reproductive toxicities). Oxidative stress is related to a variety of toxic effects induced by FTOHs. To date, few reviews have addressed the relationship between the toxicity of FTOHs and oxidative stress. This article summarises research demonstrating that the toxicity induced by FTOHs correlates with oxidative stress and metabolism. Furthermore, during the metabolic process of FTOHs, a number of cytochrome P450 enzymes (CYP450) are involved and many metabolites are produced by these enzymes, which can induce oxidative stress. This is also reviewed.

氟端粒醇的毒性与氧化应激和代谢相关。
氟调聚物醇(FTOHs)由于其独特的疏水疏油特性而被广泛用作工业原料。然而,由于意外暴露于含有FTOHs的产品或随着FTOHs的广泛使用,它们往往污染水和土壤。有报告表明,FTOHs可对动物和人类造成各种有害影响(例如,神经毒性、肝毒性、肾毒性、免疫毒性、内分泌干扰活性以及发育和生殖毒性)。氧化应激与FTOHs引起的多种毒性作用有关。迄今为止,关于FTOHs毒性与氧化应激之间关系的综述很少。本文综述了FTOHs诱导的毒性与氧化应激和代谢有关的研究。此外,FTOHs在代谢过程中涉及多种细胞色素P450酶(CYP450),这些酶产生多种代谢物,可诱导氧化应激。对此也进行了回顾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.80
自引率
0.00%
发文量
11
审稿时长
>24 weeks
期刊介绍: Reviews of Environmental Contamination and Toxicology publishes reviews pertaining to the sources, transport, fate and effects of contaminants in the environment. The journal provides a place for the publication of critical reviews of the current knowledge and understanding of environmental sciences in order to provide insight into contaminant pathways, fate and behavior in environmental compartments and the possible consequences of their presence, with multidisciplinary contributions from the fields of analytical chemistry, biochemistry, biology, ecology, molecular and cellular biology (in an environmental context), and human, wildlife and environmental toxicology. •Standing on a 55+ year history of publishing environmental toxicology reviews •Now publishing in journal format boasting rigorous review and expanded editorial board •Publishing home for extensive environmental reviews dealing with sources, transport, fate and effect of contaminants •Through Springer Compact agreements, authors from participating institutions can publish Open Choice at no cost to the authors
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