Pathogenesis of Cholangiocarcinoma.

IF 28.4 1区 医学 Q1 PATHOLOGY
Pedro M Rodrigues, Paula Olaizola, Nuno A Paiva, Irene Olaizola, Alona Agirre-Lizaso, Ana Landa, Luis Bujanda, Maria J Perugorria, Jesus M Banales
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引用次数: 55

Abstract

Cholangiocarcinoma (CCA) encompasses a group of malignancies that can arise at any point in the biliary tree. Although considered a rare cancer, the incidence of CCA is increasing globally. The silent and asymptomatic nature of these tumors, particularly in their early stages, in combination with their high aggressiveness, intra- and intertumor heterogeneity, and chemoresistance, significantly compromises the efficacy of current therapeutic options, contributing to a dismal prognosis. During the last few years, increasing efforts have been made to unveil the etiologies and pathogenesis of these tumors and to develop more effective therapies. In this review, we summarize current findings in the field of CCA, mainly focusing on the mechanisms of pathogenesis, cells of origin, genomic and epigenetic abnormalities, molecular alterations, chemoresistance, and therapies.

胆管癌的发病机制。
胆管癌(CCA)包括一组恶性肿瘤,可出现在胆道树的任何一点。虽然被认为是一种罕见的癌症,但CCA的发病率在全球范围内正在增加。这些肿瘤的沉默性和无症状性,特别是在早期阶段,再加上它们的高侵袭性、肿瘤内和肿瘤间的异质性和化疗耐药性,极大地影响了当前治疗方案的疗效,导致预后不佳。在过去的几年里,越来越多的努力已经揭示了这些肿瘤的病因和发病机制,并开发更有效的治疗方法。本文就CCA的发病机制、细胞起源、基因组和表观遗传异常、分子改变、化疗耐药和治疗等方面的研究进展进行综述。
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来源期刊
CiteScore
62.60
自引率
0.00%
发文量
40
期刊介绍: The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.
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