Efeitos do rocurônio, sugamadex e complexo rocurônio‐sugamadex sobre a coagulação em ratos

IF 1 Q3 Medicine
Ismar Lima Cavalcanti , Estêvão Luiz Carvalho Braga , Nubia Verçosa , Alberto Schanaider , Louis Barrucand , Hans Donald de Boer , Luiz Vane
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引用次数: 1

Abstract

Background and objectives

Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanism of the effects on coagulation are not fully understood. The objective of this research is to evaluate the effects of rocuronium, sugammadex and the rocuronium‐sugammadex complex on coagulation in an experimental model in rats.

Methods

This is an experimental randomized animal study. Wistar rats were randomly assigned into the following groups: the Control Group; the Ssal Group – 0.5 mL of intravenous saline; the Sugammadex Group – intravenous sugammadex (100 mg.kg‐1); and the Rocuronium‐Sugammadex Group – intravenous solution with rocuronium (3.75 mg.kg‐1) and sugammadex (100 mg.kg‐1). Anesthesia was performed by using isoflurane with controlled ventilation. Coagulation factors were measured 10 minutes after the end of the preoperative preparation and 30 minutes after the administration of the drugs in accordance with the chosen groups.

Results

Platelet counts, prothrombin times and activated partial thromboplastin times were similar between the groups and between the moments within each group. There were reductions in the plasma fibrinogen levels between sample times 1 and 2 in the Rocuronium‐Sugammadex group (p = 0.035).

Conclusions

The rocuronium‐sugammadex complex promoted reductions in plasma fibrinogen counts, although the levels were still within normal limits.

Abstract Image

罗库溴铵、苏加马定和罗库溴铵-苏加马定复合物对大鼠凝血的影响
背景和目的:sugammadex是一种能够逆转神经肌肉阻滞的替代药物,没有抗胆碱酯酶药物的局限性。与糖madex治疗相关的凝血功能障碍也有报道。对凝血作用的确切机制尚不完全清楚。本研究的目的是在实验模型中评价罗库溴铵、糖胺酮和罗库溴铵-糖胺酮复合物对大鼠凝血的影响。方法采用随机动物实验研究。Wistar大鼠随机分为两组:对照组;Ssal组:静脉注射生理盐水0.5 mL;Sugammadex组:静脉注射Sugammadex (100 mg.kg‐1);罗库溴铵- Sugammadex组-静脉注射罗库溴铵(3.75 mg.kg‐1)和Sugammadex (100 mg.kg‐1)。麻醉采用异氟醚并控制通气。在术前准备结束后10分钟和给药后30分钟,按所选组测定凝血因子。结果血小板计数、凝血酶原时间、活化部分凝血活酶时间组间及组内瞬间间无明显差异。Rocuronium - Sugammadex组血浆纤维蛋白原水平在样品次数1和2之间有所降低(p = 0.035)。结论罗库溴铵-糖胺酮复合物可促进血浆纤维蛋白原计数降低,但其水平仍在正常范围内。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.50
自引率
0.00%
发文量
0
审稿时长
21 weeks
期刊介绍: The Brazilian Journal of Anesthesiology is the official journal of the Brazilian Anesthesiology Society. It publishes articles classified into the following categories: -Scientific articles (clinical or experimental trials)- Clinical information (case reports)- Reviews- Letters to the Editor- Editorials. The journal focuses primarily on clinical trials, with scope on clinical practice, aiming at providing applied tools to the anesthesiologist and critical care physician. The Brazilian Journal of Anesthesiology accepts articles exclusively forwarded to it. Articles already published in other journals are not accepted. All articles proposed for publication are previously submitted to the analysis of two or more members of the Editorial Board or other specialized consultants.
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