Sybille Welker, Sébastien Boutin, Thomas Miethke, Klaus Heeg, Dennis Nurjadi
{"title":"Emergence of carbapenem-resistant ST131 <i>Escherichia coli</i> carrying <i>bla</i><sub>OXA-244</sub> in Germany, 2019 to 2020.","authors":"Sybille Welker, Sébastien Boutin, Thomas Miethke, Klaus Heeg, Dennis Nurjadi","doi":"10.2807/1560-7917.ES.2020.25.46.2001815","DOIUrl":null,"url":null,"abstract":"<p><p>The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 <i>Escherichia coli</i> in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing <i>E. coli</i> may be under-reported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 <i>E. coli</i> is of clinical relevance and should be monitored closely.</p>","PeriodicalId":520613,"journal":{"name":"Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678038/pdf/","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2807/1560-7917.ES.2020.25.46.2001815","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be under-reported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.