Hypolipidemic, Antioxidant and Cardioprotective Effects of the Aqueous Extract from Scorzanera Undulata Tubers in Streptozotocin-Induced Diabetic Rats.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2021-01-01 DOI:10.2174/1871525718666201013152449

Mohammed Ajebli, Ayoub Amssayef, Mohamed Eddouks

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引用次数: 2

Abstract

Aims: This study aimed to assess the effect of Scorzanera undulata on plasma lipid profile.

Background: Scorzanera undulata (S. undulata) is a medicinal plant popularly used in the Moroccan pharmacopeia as traditional medicine, particularly to treat diabetes mellitus.

Objective: The purpose of this study was to explore the effects of aqueous extract of Scorzanera undulata tubers (AERSU) on lipid profile and atherogenic indices in Wistar rats. Biochemical parameters such as Total Cholesterol (TC), triglycerides (TG), and low-and high-density lipoproteins-cholesterol (LDL and HDL) were assessed. Furthermore, the in vitro antioxidant activity of AERSU was also evaluated.

Methods: The effect of tubers aqueous extract (AERSU) of S. undulata (20 mg/kg) on plasma lipid profile was investigated in normal and streptozotocin (STZ)-induced diabetic rats. The aqueous extract was tested for its in vitro antioxidant activity. Besides, cardiovascular parameters were estimated.

Results: Treatment with AERSU significantly improved the weight in diabetic rats and decreased plasma cholesterol, triglycerides, and LDL lipoproteins levels. Furthermore, the extract had a favorable impact on the Atherogenic Index (AI) and Coronary Risk Index (CRI). In addition, AERSU seems to possess a potent in vitro antioxidant activity.

Conclusion: The study demonstrates that aqueous Scorzanera undulate extract exhibits antidyslipidemic and antioxidant activities.

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蛇尾草茎水提物对链脲佐菌素诱导的糖尿病大鼠的降血脂、抗氧化和心脏保护作用。

目的:本研究旨在探讨蛇尾草对血脂的影响。背景:荡浪形Scorzanera undulata (S. undulata)是一种药用植物，在摩洛哥药典中作为传统药物被广泛使用，特别是用于治疗糖尿病。目的:探讨山葵水提物(AERSU)对Wistar大鼠血脂及动脉粥样硬化指标的影响。评估生化参数，如总胆固醇(TC)、甘油三酯(TG)、低脂蛋白和高密度脂蛋白-胆固醇(LDL和HDL)。并对其体外抗氧化活性进行了评价。方法:采用链脲佐菌素(STZ)诱导的糖尿病大鼠和正常大鼠，研究了山楂块茎水提物(AERSU) (20 mg/kg)对糖尿病大鼠血脂的影响。测定了水提物的体外抗氧化活性。并对心血管参数进行估计。结果:AERSU治疗显著改善糖尿病大鼠体重，降低血浆胆固醇、甘油三酯和LDL脂蛋白水平。此外，提取物对动脉粥样硬化指数(AI)和冠状动脉危险指数(CRI)有良好的影响。此外，AERSU似乎具有强大的体外抗氧化活性。结论:波浪形鲉水提物具有抗血脂异常和抗氧化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.