Viral genetic diversity and its potential contributions to the development and progression of neonatal herpes simplex virus (HSV) disease.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2019-12-01 Epub Date: 2019-11-23 DOI:10.1007/s40588-019-00131-6

Lisa N Akhtar, Moriah L Szpara

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引用次数: 2

Abstract

Purpose of review: Neonatal infection by herpes simplex virus (HSV) 1 or 2 presents a devastating burden to new parents, due to the unpredictability of severe clinical outcomes, as well as the potential for lifelong reactivation. While just under half of neonatal HSV infections have mild clinical impacts akin to those observed in adults, the other half experience viral spread throughout the body (disseminated infection) and/or the brain (central nervous system infection).

Summary: Here we summarize current data on clinical diagnostic measures, antiviral therapy, and known factors of human host biology that contribute to the distinct neonatal outcomes of HSV infection.

Recent findings: We then explore recent new data on how viral genetic diversity between infections may impact clinical outcomes. Further research will be critical to build upon these early findings and to provide statistical power to our ability to discern and/or predict the potential clinical path of a given neonatal infection.

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病毒遗传多样性及其对新生儿单纯疱疹病毒(HSV)疾病的发展和进展的潜在贡献

综述目的:新生儿单纯疱疹病毒(HSV) 1或2感染对新生儿父母来说是一种毁灭性的负担，因为其严重的临床结果不可预测，并且可能终生再激活。虽然只有不到一半的新生儿HSV感染具有与成人相似的轻微临床影响，但另一半则经历病毒在全身(播散性感染)和/或大脑(中枢神经系统感染)的传播。摘要:在这里，我们总结了目前的临床诊断措施、抗病毒治疗和已知的人类宿主生物学因素，这些因素有助于新生儿HSV感染的不同结局。最近的发现:然后，我们探索了最近关于感染之间的病毒遗传多样性如何影响临床结果的新数据。在这些早期发现的基础上，进一步的研究将是至关重要的，并为我们辨别和/或预测特定新生儿感染的潜在临床路径提供统计能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.