Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-10-01 DOI:10.1177/1470320320979097

Martijn Hoevenaar, Dolf Goossens, Janne Roorda

引用次数: 7

Abstract

Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 complications (e.g. ARDS and thrombosis), and potential therapeutic targets for pharmacological intervention, will be reviewed.

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血管紧张素转换酶2、补体系统、钾化钾素-激肽系统、2型糖尿病、白细胞介素-6及其在复杂的COVID-19病理生理十字路口中的相互作用。

由于当前的covid -19大流行，世界目前正处于各种封锁之中。ACE2促进SARS-CoV-2细胞进入，是RAAS、CS、KKS、T2DM和IL-6等几种病理生理通路的核心。它们与COVID-19严重并发症(如ARDS和血栓形成)的相互作用以及药物干预的潜在治疗靶点将被回顾。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.