Cognitive Event-Related Potentials in Young Adults With Cerebral Palsy: A Proof-of-Concept Study.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Clinical EEG and Neuroscience Pub Date : 2024-01-01 Epub Date: 2020-12-03 DOI:10.1177/1550059420977318
Christine L Lackner, Jan Willem Gorter, Sidney J Segalowitz
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引用次数: 0

Abstract

Cerebral palsy (CP) is a movement and posture disorder often accompanied by cognitive difficulties which can be assessed using event-related potentials (ERPs), an often-overlooked tool in this population. Here we describe our assessment protocol, examine its feasibility, and validate the use of single-subject ERP analyses in adolescents and young adults with CP, an analysis approach which recognizes the heterogeneity of the clinical population. This study involved a final sample of 9 adolescents/young adults with CP participating in the "MyStory" study (age range 16-29 years, Mage = 25.0 years; 6 female; Gross Motor Function Classification System level I [n = 4], II [n = 2], III [n = 1], IV [n = 1], and V [n = 1]). ERP components were elicited over medial prefrontal and central cortex (error- and correct-related negativities [ERN/CRN], error-positivity [Pe], N100, P200, N200, P300), as well as those generated over occipital cortex (P100, N170). Group and single-subject ERP statistics were computed for ERPs recorded over both areas. Using recently developed data analysis methods (independent components analysis and robust bootstrapped single-subject statistics), we measured the number of participants demonstrating significant condition differences at the timing of each ERP component of interest. We demonstrate good validity for ERPs recorded during 2 of our 3 tasks eliciting frontal activation (eg, 4 of 6 participants with usable data showed a significant single-subject medial frontal negativity condition difference in a context-switching task) and good validity for ERPs derived from a task engaging occipital regions (eg, 8 of 9 participants each showed a significant N170 face-object condition effect).

青年脑瘫患者的认知事件相关电位:一项概念验证研究
脑瘫(CP)是一种运动和姿势障碍,通常伴有认知困难,可以使用事件相关电位(erp)来评估,这是该人群中经常被忽视的工具。在这里,我们描述了我们的评估方案,检查了其可行性,并验证了在青少年和年轻CP患者中使用单受试者ERP分析,这是一种认识到临床人群异质性的分析方法。本研究最终纳入了9名参与“MyStory”研究的CP青少年/年轻人(年龄范围16-29岁,年龄= 25.0岁;6女;大肌肉运动功能分类系统I级[n = 4]、II级[n = 2]、III级[n = 1]、IV级[n = 1]、V级[n = 1])。ERP成分在内侧前额叶和中央皮层(错误和正确相关的负性[ERN/CRN],错误相关的正性[Pe], N100, P200, N200, P300)以及枕叶皮层(P100, N170)产生。计算两个区域记录的ERP的组和单受试者ERP统计。使用最近开发的数据分析方法(独立成分分析和稳健的自举单受试者统计),我们测量了在每个感兴趣的ERP成分的时间表现出显着条件差异的参与者数量。我们证明了在3个激发额叶激活的任务中的2个任务中记录的erp具有良好的效度(例如,6个具有可用数据的参与者中有4个在上下文切换任务中显示出显著的单受试者内侧额叶负性条件差异),并且在涉及枕部区域的任务中产生的erp具有良好的效度(例如,9个参与者中有8个显示出显著的N170面部-物体条件效应)。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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