3 cases of variant hemoglobin Hb A2-Niigata detected by falsely high HbA1c values.

Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-08-26 DOI:10.1016/j.cca.2020.08.036

Mika Ito, Kou Sano, Masafumi Koga

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引用次数: 3

Abstract

Background: HbA1c measurements in blood are used to monitor diabetes status.

Methods: We detected 3 cases (1 diabetic case, 1 borderline diabetic case, and 1 case with normal glucose tolerance) of variant hemoglobin Hb A2-Niigata based on falsely high HbA1c values measured by high-performance liquid chromatography (HPLC).

Results: In all 3 cases, HbA1c values measured by the HPLC method were higher than the reference range whereas the HbA1c values measured by immunoassay, plasma glucose and glycated albumin were within the reference range. The results of the genetic test revealed heterozygous mutation GTG (Val) → GCG (Ala) in codon 1 of the δ-globin gene in all 3 cases, based on which Hb A2-Niigata was found. Although until now Hb A2-Niigata has been reported in 3 cases, this is the first report on Hb A2-Niigata with falsely high HbA1c values.

Conclusions: In this report, 3 cases of Hb A2-Niigata were found in a single institution in a short period; therefore, Hb A2-Niigata would exist frequently in a certain area. As a pathology causing falsely high HbA1c values, Hb A2-Niigata should be kept in mind.

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HbA1c虚高检出异型血红蛋白Hb A2-Niigata 3例。

背景:血液中HbA1c的测量用于监测糖尿病状态。方法:采用高效液相色谱法(HPLC)检测3例(1例糖尿病、1例交界型糖尿病、1例糖耐量正常)Hb A2-Niigata变异型血红蛋白。结果:3例患者，HPLC法测定的HbA1c均高于参考范围，而免疫法、血糖、糖化白蛋白测定的HbA1c均在参考范围内。基因检测结果显示，3例患者δ-珠蛋白基因密码子1杂合突变GTG (Val) → GCG (Ala)，由此发现Hb A2-Niigata。虽然到目前为止，已有3例Hb A2-Niigata报告，但这是第一例HbA1c值虚高的Hb A2-Niigata报告。结论:本报告在同一医院短时间内发现3例Hb A2-Niigata;因此，Hb A2-Niigata在某一区域会频繁存在。作为一种导致HbA1c值虚高的病理，我们应该牢记Hb A2-Niigata。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinica chimica acta; international journal of clinical chemistry

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