Zebrafish (Danio rerio) as a Model for Understanding the Process of Caudal Fin Regeneration.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-12-01 DOI:10.1089/zeb.2020.1926

Lina Lebedeva, Beibitgul Zhumabayeva, Tatyana Gebauer, Ilya Kisselev, Zaure Aitasheva

引用次数: 10

Abstract

After its introduction for scientific investigation in the 1950s, the cypriniform zebrafish, Danio rerio, has become a valuable model for the study of regenerative processes and mechanisms. Zebrafish exhibit epimorphic regeneration, in which a nondifferentiated cell mass formed after amputation is able to fully regenerate lost tissue such as limbs, heart muscle, brain, retina, and spinal cord. The process of limb regeneration in zebrafish comprises several stages characterized by the activation of specific signaling pathways and gene expression. We review current research on key factors in limb regeneration using zebrafish as a model.

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斑马鱼(Danio rerio)作为理解尾鳍再生过程的模型。

自20世纪50年代引入科学研究以来，鲤形斑马鱼(Danio rerio)已成为研究再生过程和机制的有价值的模型。斑马鱼表现出表形再生，在截肢后形成的未分化细胞团能够完全再生失去的组织，如四肢、心肌、大脑、视网膜和脊髓。斑马鱼肢体再生的过程包括几个阶段，其特征是特定信号通路的激活和基因表达。本文综述了以斑马鱼为模型的肢体再生关键因素的研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.