Zebrafish (Danio rerio) as a Model for Understanding the Process of Caudal Fin Regeneration.

IF 1.4 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

Zebrafish Pub Date : 2020-12-01 DOI:10.1089/zeb.2020.1926

Lina Lebedeva, Beibitgul Zhumabayeva, Tatyana Gebauer, Ilya Kisselev, Zaure Aitasheva

引用次数: 10

Abstract

After its introduction for scientific investigation in the 1950s, the cypriniform zebrafish, Danio rerio, has become a valuable model for the study of regenerative processes and mechanisms. Zebrafish exhibit epimorphic regeneration, in which a nondifferentiated cell mass formed after amputation is able to fully regenerate lost tissue such as limbs, heart muscle, brain, retina, and spinal cord. The process of limb regeneration in zebrafish comprises several stages characterized by the activation of specific signaling pathways and gene expression. We review current research on key factors in limb regeneration using zebrafish as a model.

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斑马鱼(Danio rerio)作为理解尾鳍再生过程的模型。

自20世纪50年代引入科学研究以来，鲤形斑马鱼(Danio rerio)已成为研究再生过程和机制的有价值的模型。斑马鱼表现出表形再生，在截肢后形成的未分化细胞团能够完全再生失去的组织，如四肢、心肌、大脑、视网膜和脊髓。斑马鱼肢体再生的过程包括几个阶段，其特征是特定信号通路的激活和基因表达。本文综述了以斑马鱼为模型的肢体再生关键因素的研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zebrafish DEVELOPMENTAL BIOLOGY-ZOOLOGY

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

3 months

期刊介绍： Zebrafish is the only peer-reviewed journal dedicated to the central role of zebrafish and other aquarium species as models for the study of vertebrate development, evolution, toxicology, and human disease. Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is a prime model for genetic and developmental studies. While genetically more distant from humans, the vertebrate zebrafish nevertheless has comparable organs and tissues, such as heart, kidney, pancreas, bones, and cartilage. Zebrafish introduced the new section TechnoFish, which highlights these innovations for the general zebrafish community. TechnoFish features two types of articles: TechnoFish Previews: Important, generally useful technical advances or valuable transgenic lines TechnoFish Methods: Brief descriptions of new methods, reagents, or transgenic lines that will be of widespread use in the zebrafish community Zebrafish coverage includes: Comparative genomics and evolution Molecular/cellular mechanisms of cell growth Genetic analysis of embryogenesis and disease Toxicological and infectious disease models Models for neurological disorders and aging New methods, tools, and experimental approaches Zebrafish also includes research with other aquarium species such as medaka, Fugu, and Xiphophorus.