Predictive Value of Red Blood Cell Distribution Width in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Embolism.

IF 2.6 4区医学 Q3 CELL BIOLOGY

Analytical Cellular Pathology Pub Date : 2020-07-21 eCollection Date: 2020-01-01 DOI:10.1155/2020/1935742

Jing Wang, Zongren Wan, Qing Liu, Baolan Wang, Liang Wang, Dan Yang, Lixin Wang, Yongqing Hong, Rong Zhu

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引用次数: 11

Abstract

Purpose: This study is aimed at investigating the relationship between red cell distribution width (RDW) and chronic obstructive pulmonary disease (COPD) patients with pulmonary embolism (PE).

Methods: We conducted a retrospective study enrolling a total of 125 patients from January 2013 to December 2019. The study group consisted of 40 COPD patients with PE, and the control group had 85 COPD patients without PE. Clinical data including demographic characteristics, comorbidities, and results of imaging examinations and laboratory tests were recorded. Blood biomarkers, including red blood cell distribution width standard deviation (RDW-SD), red blood cell distribution width coefficient of variation (RDW-CV), and D-Dimer, were included.

Results: RDW-SD and RDW-CV were higher in the COPD patients with the PE group (p < 0.001). A higher RDW-SD led to a significantly increased risk of PE than a lower RDW-SD (adjusted odds ratio (OR): 1.188; 95% confidence interval (CI): 1.048-1.348). The area under the curve (AUC) of RDW-SD used for predicting PE was 0.737. Using 44.55 as the cutoff value of RDW-SD, the sensitivity was 80% and the specificity was 64.7%. The prediction accuracy of RDW-SD combined with D-Dimer (AUC = 0.897) was higher than that of RDW-SD or D-Dimer alone. The optimal cutoff value of RDW-SD+D-Dimer for predicting PE was 0.266, which generated a sensitivity of 87.5% and specificity of 83.5%.

Conclusion: RDW is significantly increased in COPD patients with PE and may thus be useful in predicting the occurrence of PE in patients with COPD.

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红细胞分布宽度在慢性阻塞性肺疾病合并肺栓塞患者中的预测价值。

目的:探讨红细胞分布宽度(RDW)与慢性阻塞性肺疾病(COPD)合并肺栓塞(PE)的关系。方法:2013年1月至2019年12月，我们进行了一项回顾性研究，共纳入125例患者。研究组包括40例合并PE的COPD患者，对照组有85例未合并PE的COPD患者。记录临床资料，包括人口统计学特征、合并症、影像学检查和实验室检查结果。血液生物标志物包括红细胞分布宽度标准差(RDW-SD)、红细胞分布宽度变异系数(RDW-CV)和d -二聚体。结果:COPD患者合并PE组的RDW-SD和RDW-CV较高(p < 0.001)。较高的RDW-SD比较低的RDW-SD显著增加PE的风险(校正优势比(OR): 1.188;95%置信区间(CI): 1.048-1.348)。预测PE的RDW-SD曲线下面积(AUC)为0.737。以44.55作为RDW-SD的截止值，敏感性为80%，特异性为64.7%。RDW-SD联合d -二聚体的预测精度(AUC = 0.897)高于单独使用RDW-SD或d -二聚体的预测精度。RDW-SD+D-Dimer预测PE的最佳截止值为0.266，敏感性为87.5%，特异性为83.5%。结论:COPD合并PE患者的RDW显著增加，因此可能有助于预测COPD合并PE患者的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Analytical Cellular Pathology ONCOLOGY-CELL BIOLOGY

CiteScore

4.90

自引率

3.10%

发文量

审稿时长

16 weeks

期刊介绍： Analytical Cellular Pathology is a peer-reviewed, Open Access journal that provides a forum for scientists, medical practitioners and pathologists working in the area of cellular pathology. The journal publishes original research articles, review articles, and clinical studies related to cytology, carcinogenesis, cell receptors, biomarkers, diagnostic pathology, immunopathology, and hematology.