Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS
Annual review of nutrition Pub Date : 2020-09-23 Epub Date: 2020-07-06 DOI:10.1146/annurev-nutr-011720-122203
Johanne Le Beyec, Lore Billiauws, André Bado, Francisca Joly, Maude Le Gall
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引用次数: 16

Abstract

Short bowel syndrome (SBS) is a rare disease that results from extensive resection of the intestine. When the remaining absorption surface of the intestine cannot absorb enough macronutrients, micronutrients, and water, SBS results in intestinal failure (IF). Patients with SBS who suffer from IF require parenteral nutrition for survival, but long-term parenteral nutrition may lead to complications such as catheter sepsis and metabolic diseases. Spontaneous intestinal adaptation occurs weeks to months after resection, resulting in hyperplasia of the remnant gut, modification of gut hormone levels, dysbiosis, and hyperphagia. Oral nutrition and presence of the colon are two major positive drivers for this adaptation. This review aims to summarize the current knowledge of the mechanisms underlying spontaneous intestinal adaptation, particularly in response to modifications of luminal content, including nutrients. In the future, dietary manipulations could be used to treat SBS.

短肠综合征:肠道对营养的适应模式?
短肠综合征(SBS)是一种罕见的疾病,结果广泛切除肠道。当肠道的剩余吸收面不能吸收足够的宏量营养素、微量营养素和水时,SBS会导致肠衰竭(IF)。患有IF的SBS患者需要肠外营养才能生存,但长期肠外营养可能导致导管败血症和代谢性疾病等并发症。自发肠道适应发生在切除后数周至数月,导致残肠增生、肠道激素水平改变、生态失调和贪食。口腔营养和结肠的存在是这种适应的两个主要积极驱动因素。这篇综述旨在总结目前对肠道自发适应机制的了解,特别是对肠道内容(包括营养物质)改变的反应。在未来,饮食操作可用于治疗SBS。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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