Paradigms that define lung epithelial progenitor cell fate in development and regeneration.

IF 2.3 Q4 CELL & TISSUE ENGINEERING

Current Stem Cell Reports Pub Date : 2019-12-01 Epub Date: 2019-11-18 DOI:10.1007/s40778-019-00166-x

Aravind Sivakumar, David B Frank

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引用次数: 6

Abstract

Purpose of review: Throughout the lifespan, lung injury impedes the primary critical function essential for life-respiration. To repair quickly and efficiently is critical and is orchestrated by a diverse repertoire of progenitor cells and their niche. This review incorporates knowledge gained from early studies in lung epithelial morphogenesis and cell fate and explores its relevance to more recent findings of lung progenitor and stem cells in development and regeneration.

Recent findings: Cell fate in the lung is organized into an early specification phase and progressive differentiation phase in lung development. The advent of single cell analysis combined with lineage analysis and projections is uncovering new functional cell types in the lung providing a topographical atlas for progenitor cell lineage commitment during development, homeostasis, and regeneration.

Summary: Lineage commitment of lung progenitor cells is spatiotemporally regulated during development. Single cell sequencing technologies have significantly advanced our understanding of the similarities and differences between developmental and regenerative cell fate trajectories. Subsequent unraveling of the molecular mechanisms underlying these cell fate decisions will be essential to manipulating progenitor cells for regeneration.

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确定肺上皮祖细胞在发育和再生中的命运的模式。

回顾目的:在整个生命周期中，肺损伤阻碍了生命所必需的主要关键功能-呼吸。快速和有效的修复是至关重要的，是由各种各样的祖细胞和它们的生态位精心安排的。本文综述了从肺上皮细胞形态发生和细胞命运的早期研究中获得的知识，并探讨了其与肺祖细胞和干细胞在发育和再生中的最新发现的相关性。最近的研究发现:肺细胞的命运在肺发育中分为早期规范阶段和逐渐分化阶段。单细胞分析结合谱系分析和预测的出现，揭示了肺中新的功能细胞类型，为祖细胞谱系在发育、稳态和再生过程中的承诺提供了地形图谱。摘要:肺祖细胞的谱系承诺在发育过程中受到时空调控。单细胞测序技术极大地促进了我们对发育和再生细胞命运轨迹的异同的理解。随后揭开这些细胞命运决定背后的分子机制对于操纵祖细胞进行再生至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Stem Cell Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of stem cell research, therapy, ethics, commercialization, and policy. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.