Targeting gap junctional intercellular communication by hepatocarcinogenic compounds.

IF 6.4 2区医学 Q1 ENVIRONMENTAL SCIENCES

Journal of Toxicology and Environmental Health-Part B-Critical Reviews Pub Date : 2020-08-17 Epub Date: 2020-06-22 DOI:10.1080/10937404.2020.1781010

Kaat Leroy, Alanah Pieters, Andrés Tabernilla, Axelle Cooreman, Raf Van Campenhout, Bruno Cogliati, Mathieu Vinken

引用次数: 3

Abstract

Gap junctions in liver, as in other organs, play a critical role in tissue homeostasis. Inherently, these cellular constituents are major targets for systemic toxicity and diseases, including cancer. This review provides an overview of chemicals that compromise liver gap junctions, in particular biological toxins, organic solvents, pesticides, pharmaceuticals, peroxides, metals and phthalates. The focus in this review is placed upon the mechanistic scenarios that underlie these adverse effects. Further, the potential use of gap junctional activity as an in vitro biomarker to identify non-genotoxic hepatocarcinogenic chemicals is discussed.

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肝癌化合物靶向间隙连接细胞间通讯。

与其他器官一样，肝脏的间隙连接在组织稳态中起着关键作用。从本质上讲，这些细胞成分是系统性毒性和包括癌症在内的疾病的主要靶点。本文综述了损害肝间隙连接的化学物质，特别是生物毒素、有机溶剂、农药、药物、过氧化物、金属和邻苯二甲酸盐。本综述的重点放在这些不利影响的机制上。此外，本文还讨论了间隙连接活性作为一种体外生物标志物识别非遗传毒性致肝癌化学物质的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Toxicology and Environmental Health-Part B-Critical Reviews 环境科学-毒理学

CiteScore

13.80

自引率

6.90%

发文量

审稿时长

>24 weeks

期刊介绍： "Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health. Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews." The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.