{"title":"When wrinkles appear on the immune system can it be reversed?","authors":"Hiba Sibaii, Salwa Refat El-Zayat, Mona Khalil","doi":"10.1684/ecn.2020.0441","DOIUrl":null,"url":null,"abstract":"<p><p>During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and innate immunity, termed 'immunosenescence' characterized by marked changes in the composition, function, and competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body against infections, to detect and destruct malignant or autoreactive cells decline, resulting in an increase in the susceptibility to infection, development of cancer, as well as autoimmune disorders. The study of age-related changes in immune function is an important area of investigation. In this review, the function of the immune system during aging, as well as the different ways to rejuvenate the aging immune system, is explored, as medical intervention, balanced nutrition, and a healthy life style will be discussed.</p>","PeriodicalId":11749,"journal":{"name":"European cytokine network","volume":"31 1","pages":"1-17"},"PeriodicalIF":2.2000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1684/ecn.2020.0441","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European cytokine network","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1684/ecn.2020.0441","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
During aging, physiological and physical frailty occur, which is accompanied by a decline in adaptive and innate immunity, termed 'immunosenescence' characterized by marked changes in the composition, function, and competence of the human immune system. Moreover, the capabilities of the immune system to defend the human body against infections, to detect and destruct malignant or autoreactive cells decline, resulting in an increase in the susceptibility to infection, development of cancer, as well as autoimmune disorders. The study of age-related changes in immune function is an important area of investigation. In this review, the function of the immune system during aging, as well as the different ways to rejuvenate the aging immune system, is explored, as medical intervention, balanced nutrition, and a healthy life style will be discussed.
期刊介绍：
The journal that brings together all areas of work involving cytokines.
European Cytokine Network is an electronic journal that publishes original articles and abstracts every quarter to provide an essential bridge between researchers and clinicians with an interest in this cutting-edge field.
The journal has become a must-read for specialists in the field thanks to its swift publication and international circulation.
The journal is referenced in several databases, including Medline, which is testament to its scientific quality.
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