Excitability, synaptic balance, and addiction: The homeostatic dynamics of ionotropic glutamatergic receptors in VTA after cocaine exposure.

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES
Thiago C Moulin, Helgi B Schiöth
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引用次数: 0

Abstract

Glutamatergic AMPA and NMDA receptors in the ventral tegmental area (VTA) are central for cocaine first exposure and posterior craving maintenance. However, the exact rules that coordinate the synaptic dynamics of these receptors in dopaminergic VTA neurons and behavioral outcomes are poorly understood. Additionally, synaptic homeostatic plasticity is present in response to chronic excitability changes in neuronal circuits, adjusting the strength of synapses to stabilize the firing rate. Despite having correspondent mechanisms, little is known about the relationship between continuous cocaine exposure and homeostatic synaptic changes in the VTA neurons. Here, we assess the role of homeostatic mechanisms in the neurobiology of cocaine addiction by providing a brief overview of the parallels between cocaine-induced synaptic potentiation and long-term synaptic adaptations, focusing on the regulation of GluA1- and GluN1- containing receptors.

Abstract Image

兴奋性、突触平衡和成瘾:暴露于可卡因后 VTA 中离子型谷氨酸能受体的平衡动态。
腹侧被盖区(VTA)中的谷氨酸能 AMPA 和 NMDA 受体是首次接触可卡因和之后维持渴求的核心。然而,协调多巴胺能 VTA 神经元中这些受体的突触动态和行为结果的确切规则却鲜为人知。此外,神经元回路中还存在突触同态可塑性,以应对长期的兴奋性变化,调整突触强度以稳定发射率。尽管存在相应的机制,但人们对持续暴露于可卡因与 VTA 神经元中的突触稳态变化之间的关系知之甚少。在这里,我们通过简要概述可卡因诱导的突触电位和长期突触适应之间的相似之处,评估了稳态机制在可卡因成瘾的神经生物学中的作用,重点是含GluA1-和GluN1-受体的调节。
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来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
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