Abed H. Pablo, Autumn R. Breaud, William Clarke
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引用次数: 2
Abstract
Immunosuppressant medications help suppress the immune system response through inhibition of various checkpoints in the regulatory biochemical pathway. This is useful in prevention of organ rejection in transplantation or in the treatment of autoimmune diseases such as lupus or rheumatoid arthritis. Quantification of immunosuppressive drugs in blood is needed clinically for optimization of treatment and to avoid toxicity or unwanted side effects. Here, we describe a quantitative method to determine the concentration of cyclosprine A, tacrolimus, sirolimus, and everolimus in whole blood. This method has been used for many years clinically to support patient care. © 2020 by John Wiley & Sons, Inc.
液相色谱-串联质谱法分析全血中免疫抑制药物
免疫抑制药物通过抑制调节生化途径中的各种检查点来帮助抑制免疫系统反应。这对于预防器官移植中的排斥反应或治疗自身免疫性疾病如狼疮或类风湿关节炎是有用的。临床需要对血液中的免疫抑制药物进行定量，以优化治疗，避免毒性或不良副作用。在这里，我们描述了一种定量测定全血中环spring a、他克莫司、西罗莫司和依维莫司浓度的方法。这种方法在临床上已使用多年，以支持患者护理。©2020 by John Wiley &儿子,Inc。
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