Nicotinic acetylcholine receptors (rs1051730) gene polymorphism and surfactant protein D level in chronic obstructive pulmonary disease.

IF 2.7 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

British Journal of Biomedical Science Pub Date : 2020-10-01 Epub Date: 2020-06-01 DOI:10.1080/09674845.2020.1757839

Ema El Gayed, R H Elhelbawy, N G Elhelbawy

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引用次数: 2

Abstract

Chronic obstructive pulmonary disease (COPD) is a complicated disorder that may be genetically determined. It is possible that genetic determinants of nicotine addiction contribute to COPD burden. Surfactant protein D (SP-D) ensures correct ventilatory function . The aim of this work is to study serum level of (SP-D) and nicotinic acetylcholine receptors (nAChRs) (rs1051730) (G/A) gene polymorphism in COPD. We recruited 80 patients with COPD and 80 ages and gender matched healthy individuals. Estimation of Serum SP-D level (by ELISA) and genotyping of (nAChRs) (rs1051730) using TaqMan Allelic discrimination assay technique (real time PCR) were done for all individuals. Results showed significant increased serum SP-D level (P<0.001) and AA genotype and A allele frequencies in COPD patients (P< 0.001) with OR (CI) [6.15 (2.76-13.72) and 3.65 (2.29-5.78) respectively]. We conclude that AA genotype of nAChRs (rs1051730) and elevated serum level of SP-D might be risk factors for COPD.

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慢性阻塞性肺疾病烟碱乙酰胆碱受体(rs1051730)基因多态性与表面活性剂蛋白D水平的关系

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来源期刊

British Journal of Biomedical Science 医学-医学实验技术

CiteScore

4.40

自引率

15.80%

发文量

审稿时长

>12 weeks

期刊介绍： The British Journal of Biomedical Science is committed to publishing high quality original research that represents a clear advance in the practice of biomedical science, and reviews that summarise recent advances in the field of biomedical science. The overall aim of the Journal is to provide a platform for the dissemination of new and innovative information on the diagnosis and management of disease that is valuable to the practicing laboratory scientist.