Negative correlation of serum adiponectin level with peripheral artery occlusive disease in hemodialysis patients.

Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-04-02 eCollection Date: 2020-01-01 DOI:10.4103/tcmj.tcmj_19_19

Yu-Hsien Lai, Yu-Li Lin, Chih-Hsien Wang, Chiu-Huang Kuo, Bang-Gee Hsu

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Abstract

Objective: Adiponectin is a fat-derived hormone that secretes exclusively by adipocytes and has antiatherosclerotic effects. Peripheral arterial occlusive disease (PAOD) is associated with an increased risk of death in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between serum adiponectin levels and PAOD by ankle-brachial index (ABI) in HD patients.

Materials and methods: Blood samples were obtained from 100 HD patients. Serum adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. ABI values were measured using the automated oscillometric method (VaSera VS-1000). ABI values that <0.9 were included in the low ABI group.

Results: Among the 100 HD patients, 18 of them (18.0%) were in the low ABI group. Compared with patients in the normal ABI group, the patients in the low ABI group had a higher prevalence of diabetes (P = 0.043), older age (P = 0.027), and lower serum adiponectin level (P = 0.003). In addition, the multivariable logistic regression analysis showed that adiponectin (Odds ratio [OR]: 0.927, 95% confidence interval [CI]: 0.867-0.990, P = 0.025) and age (OR: 1.054, 95% CI: 1.002-1.109, P = 0.043) were the independently associated with PAOD in HD patients.

Conclusion: In this study, serum adiponectin level was found to be associated with PAOD in HD patients.

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血液透析患者血清脂肪连蛋白水平与外周动脉闭塞症呈负相关。

目的：脂肪连通素是一种源自脂肪的激素，仅由脂肪细胞分泌，具有抗动脉粥样硬化的作用。外周动脉闭塞性疾病（PAOD）与血液透析（HD）患者死亡风险的增加有关。本研究旨在通过踝肱指数（ABI）评估血液透析患者血清脂肪连蛋白水平与外周动脉闭塞性疾病之间的关系：从 100 名 HD 患者中采集血样。使用商用酶联免疫吸附试剂盒测定血清脂肪连素水平。采用自动示波法（VaSera VS-1000）测量 ABI 值。ABI值结果：在 100 名 HD 患者中，有 18 人（18.0%）属于低 ABI 组。与正常 ABI 组患者相比，低 ABI 组患者的糖尿病患病率更高（P = 0.043），年龄更大（P = 0.027），血清脂肪生成素水平更低（P = 0.003）。此外，多变量逻辑回归分析显示，脂联素（Odds ratio [OR]：0.927，95% 置信区间 [CI]：此外，多变量 logistic 回归分析表明，脂联素（Odds ratio [OR]：0.927，95% 置信区间 [CI]：0.867-0.990，P = 0.025）和年龄（OR：1.054，95% CI：1.002-1.109，P = 0.043）与 HD 患者的 PAOD 独立相关：本研究发现，血清脂肪连接蛋白水平与 HD 患者的 PAOD 相关。

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