Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, a Cross-Sectional Study.

IF 3.1 Q1 OPHTHALMOLOGY

Eye and Brain Pub Date : 2020-01-17 eCollection Date: 2020-01-01 DOI:10.2147/EB.S229814

Fatemeh Eslami, Masoud Ghiasian, Elham Khanlarzade, Ehsan Moradi

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引用次数: 11

Abstract

Background Optic neuritis (ON) is an inflammatory demyelinating lesion in the optic nerve, which is strongly associated with multiple sclerosis (MS). Optical coherence tomography (OCT) is a noninvasive technique for the evaluation of the retinal layers. Our aim was to examine OCT metrics including retinal nerve fiber layer thickness (RNFLT), and total macular volume (TMV), in MS subtypes and their relationship with duration, first manifestation, and severity of disease. Material and Methods In this cross-sectional study, patients with a definite diagnosis of MS underwent complete ophthalmic and neurologic examination. OCT parameters including TMV and RNFLT were compared between MS subtypes and different first manifestations of MS. Their relationships were also studied with the duration and severity of disease based on the Expanded Disability Status Scale (EDSS) score. Results A total of 240 eyes were examined in 120 enrolled MS patients. The differences in RNFLT were not analytically meaningful between the subtypes of MS, but the differences in TMV values were statistically significant between the subtypes of MS (P: 0.39 and P: 0.04, respectively). The differences between RNFLT and TMV of eyes with and without ON were statistically significant between these two groups (P<0.001 and P<0.001). There was also an inverse correlation between EDSS disability score and RNFLT and TMV values (P: 0.00, r: −0.33 and P: 0.034, r: −0.11, respectively) and a significant inverse correlation between the duration of MS and RNFLT (P: 0.00, r: −0.47). The differences in RNFLT and TMV values were analytically meaningful between the categories of first manifestations of MS (P: 0.000 and P: 0.027, respectively). Conclusion RNFLT and TMV represent noninvasive parameters for assessment of neuroaxonal degeneration in the anterior visual pathway that correlate with the severity and duration of multiple sclerosis. The lowest RNFLT and TMV values were also seen in the perceptual category between the first manifestations of MS. Therefore, they may be useful in the evaluation of MS patients.

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多发性硬化症亚型视网膜神经纤维层厚度和黄斑总体积及其与疾病严重程度关系的横断面研究

背景:视神经炎(ON)是一种视神经炎症性脱髓鞘病变，与多发性硬化症(MS)密切相关。光学相干断层扫描(OCT)是一种用于评估视网膜层的非侵入性技术。我们的目的是检查MS亚型的OCT指标，包括视网膜神经纤维层厚度(RNFLT)和黄斑总体积(TMV)，以及它们与病程、首次表现和疾病严重程度的关系。材料和方法:在这项横断面研究中，明确诊断为多发性硬化症的患者接受了完整的眼科和神经检查。比较MS亚型和MS不同首发表现的OCT参数TMV和RNFLT，并根据扩展残疾状态量表(EDSS)评分研究其与病程和疾病严重程度的关系。结果:120例MS患者共检查了240只眼睛。不同MS亚型间RNFLT差异无统计学意义，但不同MS亚型间TMV值差异有统计学意义(P分别为0.39和0.04)。两组有、无ON眼RNFLT和TMV差异均有统计学意义(PPP: 0.00, r: -0.33, P: 0.034, r: -0.11)， MS持续时间与RNFLT呈显著负相关(P: 0.00, r: -0.47)。不同MS首发表现类型间RNFLT和TMV值差异有统计学意义(P分别为0.000和0.027)。结论:RNFLT和TMV是评估前视通路神经轴突变性与多发性硬化症严重程度和病程相关的无创参数。RNFLT和TMV值在MS首次表现之间的知觉类别中也最低，因此它们可能对MS患者的评估有用。

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来源期刊

Eye and Brain OPHTHALMOLOGY-

CiteScore

7.90

自引率

2.30%

发文量

审稿时长

16 weeks

期刊介绍： Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.