Contributions of Eosinophils to Human Health and Disease.

IF 28.4 1区医学 Q1 PATHOLOGY

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2020-01-24 DOI:10.1146/annurev-pathmechdis-012419-032756

Amy D Klion, Steven J Ackerman, Bruce S Bochner

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引用次数: 0

Abstract

The human eosinophil has long been thought to favorably influence innate mucosal immunity but at times has also been incriminated in disease pathophysiology. Research into eosinophil biology has uncovered a number of interesting contributions by eosinophils to health and disease. However, it appears that not all eosinophils from all species are created equal. It remains unclear, for example, exactly how having eosinophils benefits the human host when helminth infections in the developed world have become scarce. This review focuses on our current state of knowledge as it relates to human eosinophils. When information is lacking, we discuss lessons learned from mouse studies that may or may not directly apply to human biology and disease. It is an exciting time to be an "eosinophilosopher" because the use of biologic agents that selectively target eosinophils provides an unprecedented opportunity to define the contribution of this cell to eosinophil-associated human diseases.

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嗜酸性粒细胞对人类健康和疾病的贡献

长期以来，人们一直认为人类嗜酸性粒细胞会对先天性粘膜免疫产生有利影响，但有时也会被认为与疾病的病理生理学有关。对嗜酸性粒细胞生物学的研究发现，嗜酸性粒细胞对健康和疾病做出了许多有趣的贡献。然而，并非所有物种的嗜酸性粒细胞都是一样的。例如，在发达世界嗜酸性粒细胞已变得稀缺的情况下，嗜酸性粒细胞对人类宿主究竟有何益处，目前仍不清楚。本综述重点介绍了我们目前对人类嗜酸性粒细胞的了解。在缺乏信息的情况下，我们将讨论从小鼠研究中吸取的教训，这些教训可能直接适用于人类生物学和疾病，也可能不适用。现在是 "嗜酸性粒细胞学家 "激动人心的时刻，因为选择性针对嗜酸性粒细胞的生物制剂的使用为确定这种细胞对嗜酸性粒细胞相关人类疾病的贡献提供了前所未有的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Pathology-Mechanisms of Disease 医学-病理学

CiteScore

62.60

自引率

0.00%

发文量

期刊介绍： The Annual Review of Pathology: Mechanisms of Disease is a scholarly journal that has been published since 2006. Its primary focus is to provide a comprehensive overview of recent advancements in our knowledge of the causes and development of significant human diseases. The journal places particular emphasis on exploring the current and evolving concepts of disease pathogenesis, as well as the molecular genetic and morphological changes associated with various diseases. Additionally, the journal addresses the clinical significance of these findings. In order to increase accessibility and promote the broad dissemination of research, the current volume of the journal has transitioned from a gated subscription model to an open access format. This change has been made possible through the Annual Reviews' Subscribe to Open program, which allows all articles published in this volume to be freely accessible to readers. As part of this transition, all articles in the journal are published under a Creative Commons Attribution (CC BY) license, which encourages open sharing and use of the research.