Epigenetics and depression
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IF 8.3 2区 医学 Q1 Medicine
Signe Penner-Goeke, Elisabeth B Binder
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引用次数: 86

Abstract

The risk for major depression is both genetically and environmentally determined. It has been proposed that epigenetic mechanisms could mediate the lasting increases in depression risk following exposure to adverse life events and provide a mechanistic framework within which genetic and environmental factors can be integrated. Epigenetics refers to processes affecting gene expression and translation that do not involve changes in the DNA sequence and include DNA methylation (DNAm) and microRNAs (miRNAs) as well as histone modifications. Here we review evidence for a role of epigenetics in the pathogenesis of depression from studies investigating DNAm, miRNAs, and histone modifications using different tissues and various experimental designs. From these studies, a model emerges where underlying genetic and environmental risk factors, and interactions between the two, could drive aberrant epigenetic mechanisms targeting stress response pathways, neuronal plasticity, and other behaviorally relevant pathways that have been implicated in major depression.
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Abstract Image

表观遗传学与抑郁症
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患重度抑郁症的风险是由基因和环境共同决定的。有人提出,表观遗传机制可以介导不良生活事件暴露后抑郁风险的持续增加,并提供了遗传和环境因素可以整合的机制框架。表观遗传学是指不涉及DNA序列变化的影响基因表达和翻译的过程,包括DNA甲基化(DNAm)和microRNAs (miRNAs)以及组蛋白修饰。在这里,我们回顾了表观遗传学在抑郁症发病机制中的作用的证据,这些证据来自于对不同组织和不同实验设计的dna、mirna和组蛋白修饰的研究。从这些研究中,出现了一个模型,其中潜在的遗传和环境风险因素,以及两者之间的相互作用,可以驱动异常的表观遗传机制,靶向应激反应途径,神经元可塑性,以及其他与重度抑郁症有关的行为相关途径。
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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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