Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles.

Q2 Medicine

Therapeutic Advances in Vaccines and Immunotherapy Pub Date : 2019-12-11 eCollection Date: 2019-01-01 DOI:10.1177/2515135519894825

Gabriela Trzewikoswki de Lima, Amanda Izeli Portilho, Elizabeth De Gaspari

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引用次数: 5

Abstract

Background: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection.

Methods: The cross-reactivity between three strains from the last outbreak of N. meningitidis in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays.

Results: Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated.

Conclusions: We observed that immunization with N. meningitidis B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.

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外膜囊泡免疫后与巴西乙型脑膜炎奈瑟菌的交叉反应性。

背景:脑膜炎奈瑟菌免疫接种对公共卫生很重要。由交叉反应性抗原组成的疫苗可避免菌株特异性反应，确保更全面的保护。方法:采用酶联免疫吸附试验(ELISA)和免疫印迹法对巴西最后一次脑膜炎奈瑟菌暴发的3株菌株进行交叉反应性评估。结果:两种方法均证实了所评估菌株之间相似的体液反应。抗原识别模式随着每次剂量的评估而不同。结论:我们观察到脑膜炎奈索菌B外膜囊泡(OMVs)免疫导致产生识别异种菌株抗原的抗体，表明可能对这些评估菌株具有保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Vaccines and Immunotherapy Medicine-Pharmacology (medical)

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

8 weeks