Neuron-Glia Signaling in Synapse Elimination.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Daniel K Wilton, Lasse Dissing-Olesen, Beth Stevens
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引用次数: 192

Abstract

Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role. Without proper functioning of these cells, the number, morphology, and function of synaptic contacts are profoundly altered, resulting in abnormal connectivity and behavioral abnormalities. In addition to their role in synaptic refinement, glial cells have also been implicated in pathological synapse loss and dysfunction following injury or nervous system degeneration in adults. Although mechanisms regulating glia-mediated synaptic elimination are still being uncovered, it is clear this complex process involves many cues that promote and inhibit the removal of specific synaptic connections. Gaining a greater understanding of these signals and the contribution of different cell types will not only provide insight into this critical biological event but also be instrumental in advancing knowledge of brain development and neural disease.

突触消除中的神经元-胶质信号传导。
神经元回路的成熟需要选择性地消除突触连接。虽然神经元内在机制在这一过程中很重要,但人们越来越认识到神经胶质细胞也起着关键作用。如果这些细胞没有正常的功能,突触接触的数量、形态和功能就会发生深刻的改变,导致连接异常和行为异常。除了在突触完善中发挥作用外,神经胶质细胞还与成人损伤或神经系统变性后的病理性突触丧失和功能障碍有关。虽然调节神经胶质介导的突触消除的机制仍未被发现,但很明显,这一复杂的过程涉及许多促进和抑制特定突触连接去除的线索。对这些信号和不同细胞类型的贡献有了更深入的了解,不仅可以深入了解这一关键的生物学事件,而且有助于提高对大脑发育和神经疾病的认识。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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