Brainstem Circuits Controlling Action Diversification.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Ludwig Ruder, Silvia Arber
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引用次数: 41

Abstract

Neuronal circuits that regulate movement are distributed throughout the nervous system. The brainstem is an important interface between upper motor centers involved in action planning and circuits in the spinal cord ultimately leading to execution of body movements. Here we focus on recent work using genetic and viral entry points to reveal the identity of functionally dedicated and frequently spatially intermingled brainstem populations essential for action diversification, a general principle conserved throughout evolution. Brainstem circuits with distinct organization and function control skilled forelimb behavior, orofacial movements, and locomotion. They convey regulatory parameters to motor output structures and collaborate in the construction of complex natural motor behaviors. Functionally tuned brainstem neurons for different actions serve as important integrators of synaptic inputs from upstream centers, including the basal ganglia and cortex, to regulate and modulate behavioral function in different contexts.

控制动作多样化的脑干回路。
调节运动的神经回路分布在整个神经系统。脑干是上部运动中枢(参与行动计划)和脊髓回路(最终导致身体运动的执行)之间的重要接口。在这里,我们关注最近的工作,利用遗传和病毒入口点来揭示功能专用和经常空间混合的脑干群体的身份,这对行动多样化至关重要,这是整个进化过程中保守的一般原则。具有独特组织和功能的脑干回路控制熟练的前肢行为、口面部运动和运动。它们将调节参数传递给运动输出结构,并在复杂的自然运动行为的构建中合作。不同行为的功能调节脑干神经元作为来自上游中枢(包括基底神经节和皮层)的突触输入的重要整合者,在不同环境下调节和调节行为功能。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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