The Healthcare Systems Research Network (HCSRN) as an Environment for Dissemination and Implementation Research: A Case Study of Developing a Multi-Site Research Study in Precision Medicine.

Alanna Kulchak Rahm, Ilene Ladd, Andrea N Burnett-Hartman, Mara M Epstein, Jan T Lowery, Christine Y Lu, Pamala A Pawloski, Ravi N Sharaf, Su-Ying Liang, Jessica Ezzell Hunter
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Abstract

Context: In existence for nearly 25 years, the Healthcare Systems Research Network (HCSRN) is an established and sustainable network of health care systems that serves as a "real world" laboratory to enable the integration of research findings into practice. The objective of this paper is to demonstrate how the HCSRN serves as an ideal environment for studying dissemination and implementation of evidence-based practices into health care systems through the example of developing a multi-site study on the implementation of evidence-based precision medicine practices.

Case description: The "Implementing Universal Lynch Syndrome Screening (IMPULSS)" study (NIH R01CA211723) involves seven HCSRN health care systems and two external health care systems. The IMPULSS study will describe and explain organizational variability around Lynch syndrome (LS) screening to identify which factors in different organizational contexts are important for successful implementation of LS screening programs and will create a toolkit to facilitate organizational decision making around implementation and improvement of precision medicine programs in health care systems.

Major themes: The strengths of the HCSRN that facilitate D&I research include: 1) a culture of collaboration, 2) standardization of data and processes across systems, and 3) researchers embedded in diverse health care systems. We describe how these strengths contributed to developing the IMPULSS study.

Conclusion: Given the importance of conducting research in real world settings to improve patient outcomes, the unique strengths of the HCSRN are of vital importance. The IMPULSS study is one case example of how the strengths of the HCSRN make it an excellent environment for research on implementing evidence-based precision medicine practices in health care systems.

Abstract Image

医疗保健系统研究网络(HCSRN)作为传播和实施研究的环境:开展精准医学多站点研究的案例研究》。
背景:医疗保健系统研究网络(HCSRN)已成立近 25 年,是一个成熟且可持续发展的医疗保健系统网络,可作为 "真实世界 "的实验室,将研究成果融入实践。本文旨在通过开展一项关于循证精准医学实践实施的多站点研究,说明 HCSRN 如何成为研究循证实践在医疗保健系统中传播和实施的理想环境:实施普遍林奇综合征筛查(IMPULSS)"研究(美国国立卫生研究院 R01CA211723)涉及七个 HCSRN 医疗保健系统和两个外部医疗保健系统。IMPULSS 研究将描述并解释围绕林奇综合征(LS)筛查的组织变异性,以确定不同组织背景下哪些因素对成功实施林奇综合征筛查计划非常重要,并将创建一个工具包,以促进医疗保健系统中围绕实施和改进精准医学计划的组织决策:HCSRN 促进 D&I 研究的优势包括1) 协作文化;2) 跨系统的数据和流程标准化;3) 研究人员融入不同的医疗保健系统。我们将介绍这些优势如何促进了 IMPULSS 研究的发展:鉴于在现实环境中开展研究以改善患者预后的重要性,HCSRN 的独特优势至关重要。IMPULSS 研究就是一个实例,说明了 HCSRN 的优势如何使其成为在医疗保健系统中实施循证精准医学实践研究的绝佳环境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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