Anticancer potential of natural products: a review focusing on Sri Lankan plants.

Frontiers in bioscience (Scholar edition) Pub Date : 2019-03-01 DOI:10.2741/S532

Anchala Kuruppu, Priyani Paranagama, Ranil De Silva

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引用次数: 10

Abstract

In the pharmaceutical industry, the expected surge in production of new therapeutic entities promised by technological advances, such as high-throughput screening, synthetic libraries and advances in molecular biology and genomics, has not materialized. The unique structural diversity of natural products continues to provide opportunities to discover novel compounds. Secondary metabolites, active components of natural products such as marine organisms, microbial organisms and terrestrial plants, are particularly exciting untapped resources for exploration as medicines. Sri Lanka is home to around 3700 plant species, half of which are considered as medicinal plants. Seventy per cent of the Sri Lankan population relies on this plant-based traditional medicine system for treating various illnesses such as tumors. As such these medicinal plant sources should be used to conquer terminal diseases and for prevention of diseases. Sri Lankan researchers have found several plant species that possess cytotoxic activity. This review summarizes the current information regarding the Sri Lankan plant materials that possess anticancer properties.

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天然产物的抗癌潜力:以斯里兰卡植物为重点。

在制药行业，技术进步(如高通量筛选、合成文库以及分子生物学和基因组学的进步)所承诺的新治疗实体生产的预期激增尚未实现。天然产物独特的结构多样性继续为发现新化合物提供机会。次生代谢物是海洋生物、微生物和陆生植物等天然产物的活性成分，是特别令人兴奋的尚未开发的药物资源。斯里兰卡有大约3700种植物，其中一半被认为是药用植物。斯里兰卡70%的人口依靠这种以植物为基础的传统医学系统来治疗各种疾病，如肿瘤。因此，这些药用植物资源应用于治疗绝症和预防疾病。斯里兰卡的研究人员发现了几种具有细胞毒活性的植物。本文综述了斯里兰卡植物抗肿瘤材料的最新研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Frontiers in bioscience (Scholar edition)

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