Targeted therapies for psoriatic arthritis: an update for the dermatologist.

Q1 Medicine
Scott A Elman, Michael Weinblatt, Joseph F Merola
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引用次数: 5

Abstract

Dermatologists are on the front line to identify psoriatic arthritis (PsA) in their patients with psoriasis. PsA is a prevalent and underdiagnosed disease with potential long-term complications and sequelae for patients. Targeted biologics have transformed the landscape of psoriasis and PsA therapy. These medications variably treat clinical manifestations of psoriatic disease: skin psoriasis, peripheral and axial arthritis, enthesitis, and nail disease. With many new medications either on the market or currently being evaluated by the Food and Drug Administration, the purpose of this article is to review PsA for the dermatologist, to identify the current therapies that are available, and to help select which patients may benefit from these medications. Overall, it is important to decide therapy for patients based on the active domains of their disease, their comorbidities, and the safety profiles of these medications, as well as patient preference for route of administration, frequency, and tolerability.

银屑病关节炎的靶向治疗:皮肤科医生的最新进展。
皮肤科医生在第一线确定银屑病患者的银屑病关节炎(PsA)。PsA是一种普遍存在但诊断不足的疾病,对患者有潜在的长期并发症和后遗症。靶向生物制剂已经改变了银屑病和PsA治疗的格局。这些药物治疗银屑病的临床表现各不相同:皮肤银屑病、周围和轴向关节炎、全身炎和指甲疾病。随着许多新药上市或正在接受食品和药物管理局的评估,本文的目的是为皮肤科医生回顾PsA,确定当前可用的治疗方法,并帮助选择哪些患者可能从这些药物中受益。总的来说,根据患者疾病的活跃域、合并症、这些药物的安全性以及患者对给药途径、频率和耐受性的偏好来决定治疗是很重要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Seminars in Cutaneous Medicine and Surgery (SCMS) presents well-rounded and authoritative discussions of important clinical areas, especially those undergoing rapid change in the specialty. Each issue, under the direction of the Editors and Guest Editors selected because of their expertise in the subject area, includes the most current information on the diagnosis and management of specific disorders of the skin, as well as the application of the latest scientific findings to patient care.
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