{"title":"[THE ROLE OF LYMPHOCYTIC RNA IN THE INTERCELLULAR INFORMATION EXCHANGE AND IN THE REGULATION OF REGENERATIVE PROCESSES].","authors":"N V Tishevskaya, A G Babaeva, N M Gevorkyan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The review presents facts telling about the involvement of RNA of lymphocytes into regulation of proliferation and differentiation of cells in various tissues. There are considered: transport mechanisms of exogenous RNAs in cells, the role of non-coding RNAs molecules in the regulation of embryonic and postnatal morphogenesis. The long non-coding RNAs and microRNAs of T-lymphocytes are characterized, also there is made a comparative analysis of different microR-NAs expression in T cells and the regulatory effects of these molecules in reparative processes. There are described the RNA technologies, stimulating the anti-tumor immunity and regeneration of damaged tissues used in clinical practice, and also the perspectives of creating new treatments based on the use of RNA preparations.</p>","PeriodicalId":21358,"journal":{"name":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","volume":"102 11","pages":"1280-1301"},"PeriodicalIF":0.0000,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The review presents facts telling about the involvement of RNA of lymphocytes into regulation of proliferation and differentiation of cells in various tissues. There are considered: transport mechanisms of exogenous RNAs in cells, the role of non-coding RNAs molecules in the regulation of embryonic and postnatal morphogenesis. The long non-coding RNAs and microRNAs of T-lymphocytes are characterized, also there is made a comparative analysis of different microR-NAs expression in T cells and the regulatory effects of these molecules in reparative processes. There are described the RNA technologies, stimulating the anti-tumor immunity and regeneration of damaged tissues used in clinical practice, and also the perspectives of creating new treatments based on the use of RNA preparations.
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