D E Korzhevskiy, O V Kirik, O S Alekseyeva, Ye G Sukhorukova, M A Syrtsova
{"title":"[INTRANUCLEAR ACCUMULATION OF Iba-1 PROTEIN IN MICROGLIOCYTES OF THE HUMAN BRAIN].","authors":"D E Korzhevskiy, O V Kirik, O S Alekseyeva, Ye G Sukhorukova, M A Syrtsova","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Iba-1 protein which is a recognized marker of the\nmicroglial cells, was previously detected by the\nauthors in the nucleus of microgliocytes. The\npresent study was aimed to define more exactly\nthese data using the methods of\nimmunohistochemistry and confocal laser\nmicroscopy. The study was performed on the\nfragments of the human brain (n=18, age 25–78\nyears). The areas examined included cortex,\nstriatum, substantia nigra, and nucleus rubrum.\nThe Iba-1 protein was shown to accumulate in one\nor several parts of microgliocyte nucleus not\nidentical to the nucleolus or the heterochromatin\ngranules. The reasons for this fact are unclear. It\nmay be speculated that Iba-1 protein besides its\nmajor function (involvement in phagocytosis) can\nperform the role of a transcriptional factor.</p>","PeriodicalId":74226,"journal":{"name":"Morfologiia (Saint Petersburg, Russia)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Morfologiia (Saint Petersburg, Russia)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Iba-1 protein which is a recognized marker of the
microglial cells, was previously detected by the
authors in the nucleus of microgliocytes. The
present study was aimed to define more exactly
these data using the methods of
immunohistochemistry and confocal laser
microscopy. The study was performed on the
fragments of the human brain (n=18, age 25–78
years). The areas examined included cortex,
striatum, substantia nigra, and nucleus rubrum.
The Iba-1 protein was shown to accumulate in one
or several parts of microgliocyte nucleus not
identical to the nucleolus or the heterochromatin
granules. The reasons for this fact are unclear. It
may be speculated that Iba-1 protein besides its
major function (involvement in phagocytosis) can
perform the role of a transcriptional factor.
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