Epithelial-myoepithelial carcinoma: a population-based survival analysis.

Q2 Medicine

BMC Ear, Nose and Throat Disorders Pub Date : 2018-08-16 eCollection Date: 2018-01-01 DOI:10.1186/s12901-018-0063-2

Mitchell R Gore

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引用次数: 31

Abstract

Background: Epithelial-myoepithelial carcinoma is an uncommon malignant neoplasm seen most frequently in the salivary glands, representing approximately 1 to 2% of salivary gland tumors. Less than 600 cases have been reported in the literature since its initial description in 1972. The aim of this study was to examine demographic, site, stage, and survival factors in patients with epithelial-myoepithelial carcinoma.

Methods: The 1973-2014 SEER (Surveillance, Epidemiology, and End Results) cancer database was queried for patients treated for epithelial-myoepithelial carcinoma. The data was analyzed for patient T (tumor), N (nodal), and M (metastasis) stage, tumor site, and demographic characteristics. The Kaplan-Meier model was used to estimate actuarial survival.

Results: A total of 468 patients were identified. White patients represented 78.0% of the total. There were 291 female patients and 177 male patients. Overall 5-, 10-, and 20-year survival was 72.7%, 59.5%, and 38.3%, respectively. Mean survival time was 165.5 months. Parotid gland was the most common site with 57.7% of patients, with submandibular gland representing 9.8% of patients. Distant metastasis (M) status was unknown in 33.3%, with 2.6% being M1, 3.0% being MX, and 61.1% M0. Nodal metastasis (N) status was unknown in 33.3%, while 4.4% were N+, 4.7% were NX, and 57.5% were N0. 88.2% of patients had surgery as part or all of the treatment regimen. Univariate Kaplan-Meier analysis showed that AJCC overall stage, primary tumor (T) stage, nodal (N) stage, presence of distant metastasis (M1), age at diagnosis, race, and non-surgical treatment significantly affected survival. On multivariate analysis age, race, AJCC stage, T, N, M stage, and treatment type were significant.

Conclusions: Epithelial-myoepithelial carcinoma is a malignant, histologically biphasic neoplasm most frequently seen in the parotid gland. The nodal and distant metastasis rates are low. Age at diagnosis, race, AJCC stage, T, N, M stage, and treatment type all significantly affected survival.

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上皮-肌上皮癌:基于人群的生存分析。

背景:上皮-肌上皮癌是一种罕见的恶性肿瘤，最常见于唾液腺，约占唾液腺肿瘤的1%至2%。自1972年首次描述以来，文献中报告的病例不足600例。本研究的目的是检查上皮-肌上皮癌患者的人口统计学、部位、分期和生存因素。方法:查询1973-2014年SEER(监测、流行病学和最终结果)癌症数据库中接受上皮-肌上皮癌治疗的患者。对患者T(肿瘤)、N(淋巴结)和M(转移)分期、肿瘤部位和人口统计学特征进行数据分析。Kaplan-Meier模型用于估计精算存活率。结果:共发现468例患者。白人患者占总数的78.0%。其中女性291例，男性177例。总体5年、10年和20年生存率分别为72.7%、59.5%和38.3%。平均生存时间165.5个月。腮腺是最常见的部位，占57.7%，颌下腺占9.8%。33.3%的远处转移(M)状态未知，其中2.6%为M1, 3.0%为MX, 61.1%为M0。33.3%的淋巴结转移(N)状态未知，而4.4%为N+， 4.7%为NX, 57.5%为N0。88.2%的患者将手术作为治疗方案的一部分或全部。单因素Kaplan-Meier分析显示，AJCC总分期、原发肿瘤(T)分期、淋巴结(N)分期、远处转移(M1)的存在、诊断年龄、种族和非手术治疗显著影响生存率。多因素分析显示，年龄、种族、AJCC分期、T、N、M分期、治疗方式有显著性差异。结论:上皮-肌上皮癌是一种组织学上双相的恶性肿瘤，最常见于腮腺。淋巴结和远处转移率低。诊断年龄、种族、AJCC分期、T、N、M分期、治疗类型均对生存率有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Ear, Nose and Throat Disorders Medicine-Otorhinolaryngology

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： BMC Ear, Nose and Throat Disorders is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of ear, nose and throat disorders, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Ear, Nose and Throat Disorders (ISSN 1472-6815) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.