Fecal pancreatic elastase-1 and erythrocyte magnesium levels in diabetes type 1 and type 2.

IF 1.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Magnesium research Pub Date : 2018-02-01 DOI:10.1684/mrh.2018.0433

Velibor Čabarkapa, Mirjana Djerić, Milena Mitrović, Sunčica Kojić-Damjanov, Ivana Isakov, Bojan Vuković, Djordje Popović

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引用次数: 3

Abstract

In both types of diabetes mellitus (DM), type 1 and type 2 (T1DM and T2DM), there are both endocrine and exocrine dysfunctions of the pancreas (PED), as well as disturbances in serum magnesium levels. The aim of this study was to examine the frequency of PED according to the level of fecal elastase-1 (FE-1) in patients with T1DM and T2DM, determining the correlation of the level of FE-1 with certain anthropometric parameters, certain indicators of metabolic regulation of diabetes, and certain nutritive markers of PED.

Materials and methods: In the examinees, (56 with T1DM (F = 35 and M = 21), 62 with T2DM (F = 30 and M = 32), and 40 in the control group (F = 19 and M = 21)), we examined anthropometric parameters, and using standard biochemical methods, we measured the level of FE-1, magnesium concentration in blood and erythrocytes, and selected blood parameters.

Results: FE-1 concentration < 200 μg/g was present in 14.2% of the examinees with T1DM, 20.9% with T2DM, and 2.5% in the control group. In all examinees with DM, there was a statistically significant correlation (P < 0.05) between the level of FE-1 and Mg concentration in the erythrocytes (R = 0.40).

Conclusions: Prevalence of pancreatic exocrine insufficiency (PEI), according to the level of FE-1, is significantly higher in patients with DM than in the control group, while it is a bit higher in patients with T2DM than the ones with T1DM. In both types of DM, Mg concentration in erythrocytes is in a significant correlation with the level of FE-1.

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1型和2型糖尿病患者粪便胰腺弹性酶-1和红细胞镁水平。

在两种类型的糖尿病(DM)中，1型和2型(T1DM和T2DM)，都存在胰腺内分泌和外分泌功能障碍(PED)，以及血清镁水平紊乱。本研究的目的是通过T1DM和T2DM患者粪便弹性酶-1 (FE-1)水平检测PED的频率，确定FE-1水平与某些人体测量参数、某些糖尿病代谢调节指标以及PED的某些营养指标的相关性。材料与方法:在T1DM患者56例(F = 35, M = 21)， T2DM患者62例(F = 30, M = 32)，对照组40例(F = 19, M = 21)中检测人体测量参数，并采用标准生化方法测定血FE-1水平、血、红细胞镁浓度及选定血液参数。结论:胰外分泌功能不全(PEI)发生率，按FE-1水平计算，DM组明显高于对照组，T2DM组略高于T1DM组。在两种类型的糖尿病中，红细胞中Mg浓度与FE-1水平显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnesium research 医学-内分泌学与代谢

CiteScore

3.50

自引率

9.40%

发文量

审稿时长

>12 weeks

期刊介绍： Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years. This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums. Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.