In vitro antioxidant properties of the biflavonoid agathisflavone.

Q1 Chemistry

Chemistry Central Journal Pub Date : 2018-06-29 DOI:10.1186/s13065-018-0443-0

Anderson Wilbur Lopes Andrade, Keylla da Conceição Machado, Katia da Conceição Machado, Daiana Dias Ribeiro Figueiredo, Jorge Mauricio David, Muhammad Torequl Islam, Shaikh Jamal Uddin, Jamil A Shilpi, Jéssica Pereira Costa

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引用次数: 31

Abstract

Purpose: Free radicals are considered as the causative agents of a variety of acute and chronic pathologies. Natural antioxidants have drawn attention of the researchers in recent years for their ability to scavenge free radicals with minimal or even no side effects. This study evaluates the antioxidant capacity of agathisflavone, a naturally occurring biflavonoid by a number of in vitro methods.

Methods: Agathisflavone was subjected to DPPH, ABTS, OH and NO radical scavenging assay, reducing potential and inhibition of lipid peroxidation (TBARS) test using trolox as a standard.

Results: Agathisflavone showed concentration-dependent antioxidant activity against all types of free radicals used in this study. The antioxidant capacity, reducing potential and inhibition of lipid peroxidation showed by agathisflavone were comparable to that of trolox.

Conclusion: Agathisflavone exhibited antioxidant capacity, which suggests considering this biflavonoid for the use in the prevention and/or treatment of diseases precipitated by oxidative stress.

Abstract Image

查看原文本刊更多论文

双类黄酮抗氧化性能的体外研究。

目的:自由基被认为是各种急慢性疾病的病原体。近年来，天然抗氧化剂因其清除自由基的能力而引起了研究人员的注意，而且几乎没有副作用。本研究评估了agathisflavone的抗氧化能力，agathisflavone是一种天然存在的双类黄酮，通过一些体外方法。方法:以trolox为标准品，对Agathisflavone进行DPPH、ABTS、OH、NO自由基清除试验、降低电位和抑制脂质过氧化(TBARS)试验。结果:Agathisflavone对本研究中使用的各种自由基具有浓度依赖性的抗氧化活性。agathisflavone的抗氧化能力、还原潜力和对脂质过氧化的抑制作用与trolox相当。结论:Agathisflavone具有抗氧化能力，可用于预防和/或治疗氧化应激引起的疾病。

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来源期刊

Chemistry Central Journal 化学-化学综合

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

3.5 months

期刊介绍： BMC Chemistry is an open access, peer reviewed journal that considers all articles in the broad field of chemistry, including research on fundamental concepts, new developments and the application of chemical sciences to broad range of research fields, industry, and other disciplines. It provides an inclusive platform for the dissemination and discussion of chemistry to aid the advancement of all areas of research. Sections: -Analytical Chemistry -Organic Chemistry -Environmental and Energy Chemistry -Agricultural and Food Chemistry -Inorganic Chemistry -Medicinal Chemistry -Physical Chemistry -Materials and Macromolecular Chemistry -Green and Sustainable Chemistry