Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study.

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Biomarker Insights Pub Date : 2018-06-04 eCollection Date: 2018-01-01 DOI:10.1177/1177271918777760

Ghaleb Bin Huraib, Fahad Al Harthi, Misbahul Arfin, Mohammed Al-Sugheyr, Sadaf Rizvi, Abdulrahaman Al-Asmari

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引用次数: 7

Abstract

The cause of atopic dermatitis (AD) is multifactorial and a number of genes including cytokines have been involved. We genotyped 315 subjects for polymorphisms in TNF-α and TNF-β and IL-10 genes. Patients had significantly higher frequency of GA genotype of TNF-α (-308 G/A) than healthy controls. Patients with AD and controls had similar distribution of A and G alleles. Genotype AA was found in 7.11% of controls while completely absent in cases. The frequencies of genotypes GG and AA of TNF-β (+252 A/G) polymorphism were higher whereas the frequency of genotype GA was significantly lower in patients than the controls. The frequencies of genotypes GG and AA of IL-10 (1082 G/A) polymorphism were significantly increased whereas genotype GA was decreased in patients than the controls. It is concluded that TNF-α (-308 G/A), TNF-β (+252 A/G), and IL-10 (-1082 G/A) polymorphisms are linked with the susceptibility of AD in Saudis and can be a risk factor.

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沙特特应性皮炎患者的细胞因子基因多态性:一项病例对照研究

特应性皮炎(AD)的病因是多因素的，包括细胞因子在内的许多基因都参与其中。我们对315名受试者进行了TNF-α、TNF-β和IL-10基因多态性的基因分型。肿瘤坏死因子-α GA基因型的频率(-308 G/A)明显高于健康对照组。AD患者和对照组的A和G等位基因分布相似。对照组中有7.11%存在AA基因型，病例中完全不存在AA基因型。肿瘤坏死因子-β (+252 A/G)多态性基因型GG和AA的频率较高，基因型GA的频率明显低于对照组。IL-10 (1082 G/A)多态性GG和AA基因型频率显著高于对照组，GA基因型频率显著低于对照组。结论:TNF-α (-308 G/A)、TNF-β (+252 A/G)和IL-10 (-1082 G/A)多态性与沙特人AD易感性相关，可能是危险因素。

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来源期刊

Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.