How T cells go rogue in the absence of Roquins.

Abstract

Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3⁺ T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).