{"title":"The Problem: Relevance, Quality, and Homogeneity of Trial Designs, Outcomes, and Reporting.","authors":"Gerd Göstemeyer, Colin Levey","doi":"10.1159/000487841","DOIUrl":null,"url":null,"abstract":"<p><p>Clinical trials are the cornerstone of evidence-based medicine. By directly comparing different interventions they produce evidence on their relative efficacy and effectiveness This, in turn, can inform secondary research and guideline development to facilitate evidence-based clinical decision making. However, the quality of evidence stemming from clinical trials is frequently poor. Here, the pathway of evidence from basic research to the generation of implementable clinical guidelines will be described. Relevant factors related to trial design and reporting, such as the choice of trial comparators, outcomes and outcome measures, will be described and their influence on evidence synthesis will be discussed. Finally, recommendations on how to improve trials in order to increase their usefulness for evidence generation will be given.</p>","PeriodicalId":35771,"journal":{"name":"Monographs in Oral Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487841","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monographs in Oral Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000487841","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/5/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 3
Abstract
Clinical trials are the cornerstone of evidence-based medicine. By directly comparing different interventions they produce evidence on their relative efficacy and effectiveness This, in turn, can inform secondary research and guideline development to facilitate evidence-based clinical decision making. However, the quality of evidence stemming from clinical trials is frequently poor. Here, the pathway of evidence from basic research to the generation of implementable clinical guidelines will be described. Relevant factors related to trial design and reporting, such as the choice of trial comparators, outcomes and outcome measures, will be described and their influence on evidence synthesis will be discussed. Finally, recommendations on how to improve trials in order to increase their usefulness for evidence generation will be given.
期刊介绍：
For two decades, ‘Monographs in Oral Science’ has provided a source of in-depth discussion of selected topics in the sciences related to stomatology. Senior investigators are invited to present expanded contributions in their fields of special expertise. The topics chosen are those which have generated a long-standing interest, and on which new conceptual insights or innovative biotechnology are making considerable impact. Authors are selected on the basis of having made lasting contributions to their chosen field and their willingness to share their findings with others.
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