Complementary, Alternative and Integrative Medicine for Childhood Atopic Dermatitis.

IF 4.2 Q3 Pharmacology, Toxicology and Pharmaceutics
Kam Lun Hon, Alexander K C Leung, Theresa N H Leung, Vivian W Y Lee
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引用次数: 13

Abstract

Background: Atopic Dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM).

Objective: This article reviews the pathophysiology of AD, clinical trials and recent patents involving various modalities of CAM in the treatment of AD.

Methods: A Medline/Pubmed search was conducted using Clinical Queries with the key terms "Chinese Medicine OR Complementary and Alternative medicine" AND "Eczema OR Atopic dermatitis". The search strategy included meta-analyses, Randomized Controlled Trials (RCTs), clinical trials, reviews and pertinent references. Patents were searched using the key term "atopic dermatitis" from www.google.com/patents, www.uspto.gov, and www.freepatentsonline.com.

Results: Only a few RCTs evaluated the efficacy of Chinese medicinal herbs in treating AD. There was some evidence for other modalities of CAM. Integrative Medicine (IM) usually refers to the various forms of CAM that combine conventional western medicine and Chinese medicine. Supporting evidence for the efficacy of IM in the treatment of AD is presently lacking. Integration is difficult. Western medicine practitioners are often ignorant about CAM and IM. Parents are concerned about the potential side effects of Western medicine and will tend to be non-compliant with the conventional Western component of IM. Recent patents on CAM and IM are reviewed. Most CAM patents are herbal compositions, evidence on their efficacy is generally lacking.

Conclusion: AD is a complex disease. The psychodynamics of the child and his/her family is the reason for the often suboptimal outcomes. Both Western and CAM practitioners should collaborate to create a mutually encouraging environment for the advances of IM. CAM and IM publications and patents are reviewed. Evidence of their efficacy is generally lacking. Further research is needed.

儿童特应性皮炎的补充、替代和综合医学。
背景:特应性皮炎(AD)是一种伴有瘙痒、睡眠障碍和生活质量差的慢性复发性皮肤病。阿尔茨海默病的治疗包括使用润肤剂、局部和全身免疫调节剂。许多患者还使用补充和替代医学(CAM)。目的:本文综述了AD的病理生理学,临床试验和最近的专利涉及各种形式的CAM治疗AD。方法:以“中医或补充替代医学”和“湿疹或特应性皮炎”为关键词,通过Medline/Pubmed检索。检索策略包括meta分析、随机对照试验(RCTs)、临床试验、综述和相关参考文献。使用关键词“特应性皮炎”从www.google.com/patents, www.uspto.gov和www.freepatentsonline.com.Results中检索专利:只有少数随机对照试验评估了中药治疗AD的疗效。有一些证据表明CAM的其他形式。中西医结合医学(IM)通常是指结合传统西医和中医的各种形式的CAM。目前缺乏支持IM治疗AD有效性的证据。整合是困难的。西医从业者往往对CAM和IM一无所知。家长们担心西药的潜在副作用,并倾向于不遵守传统的西药成分。对CAM和IM的最新专利进行了综述。大多数CAM专利是草药成分,关于其功效的证据通常缺乏。结论:AD是一种复杂的疾病。孩子和他/她的家庭的心理动力学是导致不理想结果的原因。西方和CAM从业者应该合作,为IM的进步创造一个相互鼓励的环境。回顾了CAM和IM的出版物和专利。它们的有效性普遍缺乏证据。需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
0
期刊介绍: Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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