The epidemiology of supernumerary teeth and the associated molecular mechanism.

IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Organogenesis Pub Date : 2017-07-03 Epub Date: 2017-06-09 DOI:10.1080/15476278.2017.1332554
Xi Lu, Fang Yu, Junjun Liu, Wenping Cai, Yumei Zhao, Shouliang Zhao, Shangfeng Liu
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引用次数: 43

Abstract

Supernumerary teeth are common clinical dental anomalies. Although various studies have provided abundant information regarding genes and signaling pathways involved in tooth morphogenesis, which include Wnt, FGF, BMP, and Shh, the molecular mechanism of tooth formation, especially for supernumerary teeth, is still unclear. In the population, some cases of supernumerary teeth are sporadic, while others are syndrome-related with familial hereditary. The prompt and accurate diagnosis of syndrome related supernumerary teeth is quite important for some distinctive disorders. Mice are the most commonly used model system for investigating supernumerary teeth. The upregulation of Wnt and Shh signaling in the dental epithelium results in the formation of multiple supernumerary teeth in mice. Understanding the molecular mechanism of supernumerary teeth is also a component of understanding tooth formation in general and provides clinical guidance for early diagnosis and treatment in the future.

Abstract Image

多牙的流行病学及相关分子机制。
多生牙齿是临床上常见的牙齿畸形。尽管各种研究已经提供了丰富的信息,包括Wnt、FGF、BMP和Shh等参与牙齿形态发生的基因和信号通路,但牙齿形成的分子机制,特别是多牙形成的分子机制仍不清楚。在人群中,有些多牙病例是散发的,而另一些则是与家族遗传有关的综合征。及时准确地诊断与综合征相关的多牙对某些特殊疾病是非常重要的。小鼠是研究多牙最常用的模型系统。小鼠牙上皮中Wnt和Shh信号的上调可导致多牙的形成。了解多生牙的分子机制也是全面了解牙齿形成的一个组成部分,为今后的早期诊断和治疗提供临床指导。
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来源期刊
Organogenesis
Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY
CiteScore
4.10
自引率
4.30%
发文量
6
审稿时长
>12 weeks
期刊介绍: Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.
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