Neuroanatomic Variations in Graves' Dysthyroid Ophthalmopathy as Studied With MRI.

Transactions of the American Ophthalmological Society Pub Date : 2016-08-01 Epub Date: 2017-05-24
Rona Z Silkiss, Alex R Wade
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Abstract

Purpose: To evaluate whether patients with Graves' dysthyroid ophthalmopathy (GDO) have changes in brain anatomy that can be assessed by neuroimaging as compared to age-matched controls.

Methods: We examined 10 female, euthyroid patients with GDO and 14 age and gender matched controls using high-resolution structural MRI scanning. An automatic cortical segmentation algorithm was used to estimate the thickness of each subject's gray matter across the brain. The resulting cortical thickness measurements were transferred to a standard reference space via a template-based warping procedure. A statistical analysis of between-group cortical thickness differences using a general linear model with a combination of cluster-based and bootstrapped corrections for multiple comparisons was performed.

Results: Patients with GDO have statistically significant thinning of the gray matter sheet in a minimum of eight locations: six in the right hemisphere (insula, paracentral, precuneus, superior frontal cingulate, superioparietal and postcentral) and two in the left hemisphere (lateral occipital sulcus, fusiform gyrus). Left hemisphere thinning occurred in portions of the occipital lobe while right hemisphere thinning occurred in a set of frontal and parietal areas known to be involved in self-evaluation and emotional and cognitive regulation.

Conclusion: Patients with GDO exhibit localized changes in gray matter thickness. These changes may be associated with cognitive changes reported by GDO patients. Further research before and after treatment with larger patient cohorts and experimental protocols including psychiatric evaluation and functional MRI are recommended.

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Graves甲状腺功能障碍眼病的MRI研究。
目的:评价Graves甲状腺功能障碍眼病(GDO)患者与年龄匹配的对照组相比,是否存在可通过神经影像学评估的脑解剖结构变化。方法:我们使用高分辨率结构MRI扫描检查了10名女性甲状腺功能正常的GDO患者和14名年龄和性别匹配的对照组。使用一种自动皮层分割算法来估计每个受试者在整个大脑中的灰质厚度。由此产生的皮质厚度测量值通过基于模板的翘曲过程转移到标准参考空间。对组间皮质厚度差异进行统计分析,采用基于聚类和自举校正的综合线性模型进行多重比较。结果:GDO患者至少有8个部位的灰质薄变有统计学意义:6个在右半球(脑岛、中央旁、楔前叶、额扣带上、顶叶上和中央后),2个在左半球(枕外侧沟、梭状回)。左半球变薄发生在枕叶的部分区域,而右半球变薄发生在额叶和顶叶的一组区域,这些区域已知与自我评价、情绪和认知调节有关。结论:GDO患者表现为局部脑灰质厚度改变。这些变化可能与GDO患者报告的认知变化有关。建议在治疗前后进一步研究更大的患者队列和实验方案,包括精神病学评估和功能MRI。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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