Wnt signaling pathway in retinal vascularization.

IF 3.1 Q1 OPHTHALMOLOGY
Eye and Brain Pub Date : 2016-08-09 eCollection Date: 2016-01-01 DOI:10.2147/EB.S94452
Kimberly A Drenser
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引用次数: 33

Abstract

Wnt-signaling, a ubiquitous pathway that directs differentiation, cell polarity, and tissue specificity, has been implicated as an important gene-expression pathway in retinal development. An increasing body of evidence supports the importance of Wnt-signaling, and specifically, norrin-mediated Wnt-signaling in retinal development and retinal maintenance. Gene mutations affecting the Wnt-signaling pathways result in a variety of inherited vitreoretinopathies. Additionally, there is growing evidence that prematurity and associated retinopathy are associated with alterations in the Wnt-signaling pathways. Further investigations may allow for improved diagnoses, management, and therapies in the future.

Abstract Image

Abstract Image

Abstract Image

视网膜血管化中的Wnt信号通路。
wnt信号是一种普遍存在的指导分化、细胞极性和组织特异性的途径,已被认为是视网膜发育中重要的基因表达途径。越来越多的证据支持wnt信号,特别是调节蛋白介导的wnt信号在视网膜发育和视网膜维持中的重要性。影响wnt信号通路的基因突变导致多种遗传性玻璃体视网膜病变。此外,越来越多的证据表明,早产和相关的视网膜病变与wnt信号通路的改变有关。进一步的调查可能会在未来改善诊断、管理和治疗。
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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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