Olmesartan.

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-03-31 DOI:10.1016/bs.podrm.2017.02.005

Abdulrahman A Al-Majed, Ahmed H H Bakheit, Hatem A Abdel Aziz, Abdulelah A M Al-Jallal

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引用次数: 5

Abstract

Olmesartan is an angiotensin receptor blockers with actions similar to those of losartan; it is used for the treatment of high blood pressure by relaxing blood vessels for this reason blood can flow more easily. It could be used alone or in combination with other antihypertensive drugs. This chapter gives a comprehensive profile of olmesartan, containing detailed nomenclature, formulae, elemental analysis, and appearance of the drug. In addition this chapter also describes several methods of synthesis and usage of the olmesartan. The profile covers the physicochemical properties including pK_a value, solubility, X-ray powder diffraction, melting point, and procedures of analysis (compendial, spectroscopic, electrochemical, and chromatographic techniques of analysis). Comprehensive pharmacology is also presented (pharmacological actions, therapeutic uses and dosing, interactions, and adverse effects and precautions). Eighty references were given as a proof of the above-mentioned studies.

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不要。

奥美沙坦是一种血管紧张素受体阻滞剂，作用与氯沙坦相似;它通过放松血管来治疗高血压，因此血液可以更容易地流动。它可以单独使用，也可以与其他抗高血压药物合用。本章给出了奥美沙坦的全面概况，包括详细的命名、配方、元素分析和药物外观。此外，本章还介绍了奥美沙坦的几种合成方法和用法。该概况涵盖了物理化学性质，包括pKa值，溶解度，x射线粉末衍射，熔点和分析程序(药理学，光谱，电化学和色谱分析技术)。还介绍了综合药理学(药理作用，治疗用途和剂量，相互作用，不良反应和注意事项)。本文提供了80篇参考文献作为上述研究的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量