Pathogenic factors of Pseudomonas aeruginosa - the role of biofilm in pathogenicity and as a target for phage therapy.

IF 0.3
Fairoz Al-Wrafy, Ewa Brzozowska, Sabina Górska, Andrzej Gamian
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引用次数: 87

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that can cause several acute and chronic infections in humans, and it has become an important cause of nosocomial infections and antibiotic resistance. Biofilm represents an important virulence factor for these bacteria, plays a role in P. aeruginosa infections and avoidance of immune defence mechanisms, and has the ability to protect the bacteria from antibiotics. Alginate, Psl and Pel, three exopolysaccharides, are the main components in biofilm matrix, with many biological functions attributed to them, especially with respect to the protection of the bacterial cell from antibiotics and the immune system. Pseudomonas infections, biofilm formation and development of resistance to antibiotics all require better understanding to achieve the best results using alternative treatment with phage therapy. This review describes the P. aeruginosa pathogenicity and virulence factors with a special focus on the biofilm and its role in infection and resistance to antibiotics and summarizes phage therapy as an alternative approach in treatment of P. aeruginosa infections.

铜绿假单胞菌的致病因素——生物膜在致病性中的作用及作为噬菌体治疗靶点的研究。
铜绿假单胞菌是一种条件致病菌,可引起人体多种急慢性感染,已成为医院感染和抗生素耐药的重要原因。生物膜是这些细菌的重要毒力因子,在铜绿假单胞菌感染和避免免疫防御机制中起作用,并具有保护细菌免受抗生素侵害的能力。藻酸盐、Psl和Pel三种胞外多糖是生物膜基质的主要成分,具有许多生物学功能,特别是在保护细菌细胞免受抗生素和免疫系统的侵害方面。假单胞菌感染、生物膜形成和抗生素耐药性的发展都需要更好地了解,以便利用噬菌体治疗的替代治疗取得最佳效果。本文综述了铜绿假单胞菌的致病性和毒力因素,重点介绍了生物膜及其在感染和抗生素耐药性中的作用,并总结了噬菌体治疗是铜绿假单胞菌感染的一种替代方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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