Ricardo Jorge Dinis-Oliveira, Teresa Mãgalhaes, Odília Queirós, Jorge Brandão Proença, Roxana Moreira, Maria de Lourdes Bastos, Félix Carvalho
{"title":"Signs and Related Mechanisms of Ethanol Hepatotoxicity.","authors":"Ricardo Jorge Dinis-Oliveira, Teresa Mãgalhaes, Odília Queirós, Jorge Brandão Proença, Roxana Moreira, Maria de Lourdes Bastos, Félix Carvalho","doi":"10.2174/1874473708666150916113352","DOIUrl":null,"url":null,"abstract":"<p><p>Ethanol is the most abused psychoactive substance. Accordingly to World Health Organization ethanol ranks among the top five risk factors for disease, disability and death (3.3 million/year) throughout the world. This manuscript highlights and critically analyses clinical and forensic signs related to hepatoxicity of ethanol that may lead to suspected of abuse. Namely, steatosis, jaundice, cirrhosis, hemorrhoids, esophageal varices caput medusae, ascites, petechiae, ecchymoses, splenomegaly, hemochromatosis, xanthelasma, nutritional deficiency, testicular atrophy, gynecomastia and dilated congestive cardiomyopathy are discussed and related to the toxic mechanism of ethanol. </p>","PeriodicalId":72730,"journal":{"name":"Current drug abuse reviews","volume":"8 2","pages":"86-103"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug abuse reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874473708666150916113352","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
Ethanol is the most abused psychoactive substance. Accordingly to World Health Organization ethanol ranks among the top five risk factors for disease, disability and death (3.3 million/year) throughout the world. This manuscript highlights and critically analyses clinical and forensic signs related to hepatoxicity of ethanol that may lead to suspected of abuse. Namely, steatosis, jaundice, cirrhosis, hemorrhoids, esophageal varices caput medusae, ascites, petechiae, ecchymoses, splenomegaly, hemochromatosis, xanthelasma, nutritional deficiency, testicular atrophy, gynecomastia and dilated congestive cardiomyopathy are discussed and related to the toxic mechanism of ethanol.