MicroRNA-mediated control of Epstein–Barr virus infection and potential diagnostic and therapeutic implications

IF 5.7 2区 医学 Q1 VIROLOGY
Rebecca L Skalsky
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引用次数: 1

Abstract

Herpesviruses, such as Epstein–Barr virus (EBV), encode multiple viral microRNAs that are expressed throughout various infection stages. While much progress has been made in evaluating both the viral and host microRNAs (miRNAs) that are detected during infection as well as elucidating their molecular targets in vitro, our understanding of their contributions to pathogenesis in vivo, viral oncogenesis, and clinical implications for these small molecules remains limited. miRNAs are widely recognized as key regulators of global cellular processes, including apoptosis, cell differentiation, and development of immune responses. This review discusses the roles of miRNAs in EBV infection and current advances in miRNA-based diagnostic and therapeutic strategies potentially applicable toward EBV-associated diseases.

microrna介导的eb病毒感染控制及其潜在的诊断和治疗意义
疱疹病毒,如eb病毒(Epstein-Barr virus, EBV),编码多个病毒microrna,这些microrna在不同的感染阶段表达。虽然在评估感染过程中检测到的病毒和宿主microrna (mirna)以及阐明其体外分子靶点方面取得了很大进展,但我们对这些小分子在体内发病机制、病毒肿瘤发生和临床意义方面的贡献的理解仍然有限。mirna被广泛认为是全球细胞过程的关键调节剂,包括凋亡、细胞分化和免疫反应的发展。本文综述了mirna在EBV感染中的作用,以及基于mirna的诊断和治疗策略的最新进展,这些策略可能适用于EBV相关疾病。
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来源期刊
CiteScore
11.80
自引率
5.10%
发文量
76
审稿时长
83 days
期刊介绍: Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.
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