Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2022-08-22 DOI:10.1002/cdt3.41

Sha Liu, Zhenglong Guo, Hongbao Cao, Hong Li, Xiaodong Hu, Long Cheng, Jianying Li, Ruize Liu, Yong Xu

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引用次数: 2

Abstract

Background

Schizophrenia (SCZ) is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure. Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics. We aimed to explore the state of thalamic lateralization of SCZ.

Methods

We used voxel-based morphometry (VBM) analysis, whole-brain analysis of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), and resting-state seed-based functional connectivity (FC) analysis to investigate brain structural and functional deficits in SCZ. Also, we applied Pearson's correlation analysis to validate the correlation between Positive and Negative Symptom Scale (PANSS) scores and them.

Results

Compared with healthy controls, SCZ showed increased gray matter volume (GMV) of the left thalamus (t = 2.214, p = 0.029), which positively correlated with general psychosis (r = 0.423, p = 0.010). SCZ also showed increased ALFF in the putamen, the caudate nucleus, the thalamus, fALFF in the nucleus accumbens (NAc), and the caudate nucleus, and decreased fALFF in the precuneus. The left thalamus showed significantly weaker resting-state FC with the amygdala and insula in SCZ. PANSS negative symptom scores were negatively correlated with the resting-state FC between the thalamus and the insula (r = −0.414, p = 0.025).

Conclusions

Collectively, these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.

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首发精神分裂症患者左丘脑静息状态MRI不对称性的改变

精神分裂症(SCZ)是一种复杂的精神障碍，与大脑皮层下结构的广泛改变有关。大脑半球不对称是人类大脑的基本组织原理，与人类的心理和行为特征有关。我们的目的是探讨丘脑侧化的状态。方法采用基于体素的形态学分析(VBM)、全脑低频波动分析(ALFF)、低频波动分数幅值(fALFF)和基于静息状态种子的功能连接(FC)分析来研究SCZ的大脑结构和功能缺陷。此外，我们应用Pearson相关分析来验证阳性和阴性症状量表(PANSS)得分与他们之间的相关性。结果与健康对照组相比，SCZ组左丘脑灰质体积(GMV)增加(t = 2.214, p = 0.029)，与一般精神病呈正相关(r = 0.423, p = 0.010)。SCZ还显示壳核、尾状核、丘脑的ALFF升高，伏隔核和尾状核的ALFF升高，楔前叶的ALFF降低。在SCZ中，左丘脑与杏仁核和岛岛的静息状态FC明显减弱。PANSS阴性症状评分与丘脑和脑岛间静息状态FC呈负相关(r = - 0.414, p = 0.025)。综上所述，这些结果提示了左丘脑及其FC与其他与边缘系统相关的大脑区域存在异常偏侧的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.